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DermExcel™ | Salicylic Gel
Salicylic Gel
Salicylic Gel Salicylic Gel Salicylic Gel Salicylic Gel
DermExcel™

Salicylic Gel

4.9 / 5.0 from 464 reviews
↓ Sebum

↓ Sebum

Unclog Pores

Unclog Pores

Anti-Acne

Anti-Acne

↓ inflammation

↓ inflammation

Ingrown hair

Ingrown hair

Salicylic Gel is a scientifically formulated chemical exfoliating treatment enriched with 5% Salicylic acid, renowned for its potent anti-inflammatory, oil-regulating, and cell-resurfacing properties. This advanced gel is meticulously designed to combat acne and folliculitis by effectively inhibiting the growth of acne-causing bacteria. It efficiently reduces irritation and inflammation associated with these conditions, relieving troubled skin.

With its optimal concentration of Salicylic acid, Salicylic Gel clears existing acne and folliculitis lesions, promoting a smoother and healthier complexion. By gently exfoliating the skin's surface, it aids in cell turnover, diminishing the appearance of blemishes and scars over time.

Featuring its primary active ingredient, Salicylic acid, this targeted gel provides a safe and reliable solution to tackle breakouts effectively. Regulating the skin's sebum production helps prevent future breakouts, addressing the root cause of acne and folliculitis. Salicylic Gel is a valuable addition to any skincare routine, particularly for those seeking a scientifically backed solution to troublesome skin conditions.

Salicylic acid
Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, Salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects
  • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
  • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
  • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
  • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
  • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.

Role in Managing Dermatological Conditions
  • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
  • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
  • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
  • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
  • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References
  • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
  • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
  • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
  • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Salicylic Gel Salicylic Gel Salicylic Gel Salicylic Gel
DermExcel™ | Salicylic Gel
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  • Acne: Clear existing lesions and prevent future breakouts. Its anti-inflammatory action reduce redness and inflammation associated with acne, while its oil-regulating effects help control sebum production.
  • Folliculitis: Help manage the inflammation of hair follicles and inhibit the growth of bacteria that contribute to folliculitis.
  • Oily skin: Regulate and control excessive sebum production, reducing shine and helping prevent clogged pores.
  • Rough Skin Texture: Enhance skin smoothness, minimize roughness, and refine the appearance of pores, resulting in a more even and refined complexion.
  • Congested Pores: Oil soluble and, therefore, able to penetrate the pores to dissolve oil and cell debris to unclog pores.
  • Psoriasis: Soften and remove scales associated with psoriasis due to its keratolytic action.
  • Keratosis Pilaris: Reduce the appearance of rough, bumpy skin associated with this condition.

Active ingredients
  • Salicylic acid
    • Salicylic acid

    Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.

    Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.

    What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

    Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, Salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.
    • Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
    • Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
    • Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
    • Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
    • Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.
    • Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
    • Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
    • Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
    • Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
    • Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.
    • Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
    • Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
    • Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
    • Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Full ingredient list

    Aqua, Propylene glycol, Glycolic acid, Glycerin, Polyacrylamide & C13-14 Isoparaffin & Laureth-7, Triethanolamine, Hydroxyethylcellulose, Potassium hydroxide

Evening
  • Application time: Evening.
  • Frequency: 2-3 times per week as tolerated by your skin, or follow your Dermal Diagnosis treatment plan instructions. Once an affected area becomes clear, occasional use will maintain remission. 

1. Cleanse
  • Start with clean and dry skin.
  • Use your DermExcel cleanser to remove dirt and excess oil from your skin.

2: Apply
  • Dispense a small amount of product onto your fingertips.
  • Apply evenly over your face or on body areas of concern.
  • Avoid sensitive areas, e.g., the eyes and lips.

Important note
  • Start by applying this exfoliator one evening per week. After one week, increase usage to two evenings a week.
  • Observe how your skin responds and adjust usage accordingly.
  • You may use this treatment every second night if you don't have sensitive skin.
  • Don't apply any other product to the area treated with your exfoliating treatment. The other product may alter the pH of the active ingredients, lowering the product's potency. 
  • This exfoliating treatment promotes skin peeling by effectively removing dead skin cells. Peeling is a normal reaction and not a sign of skin dryness. You should notice decreased peeling as the product works to exfoliate dead skin.
  • You may notice a slight stickiness on your skin after applying your exfoliating product. This sensation is typical due to the hydroxyethylcellulose, a thickening agent that helps the treatment adhere to the skin. This allows the active ingredients to work effectively throughout the night by promoting exfoliation and cell turnover. Embrace this as a sign that the active ingredients are set to rejuvenate your skin while you sleep without the inconvenience of daytime residue.
  • Always use SPF 30 or greater during the day.

salicylic gel

mode of action

the stages of acne

Step 1

Step 1

Regulate sebum (oil) production and secretion

  • The excretion of lipids by the sebaceous glands is controlled hormonally.
  • The sebaceous glands are located all over the body but are the largest and most numerous in the face, back, chest, and shoulders.
  • These glands become more active during puberty because of increased androgens, particularly testosterone, which spurs sebum production.
  • This imbalance between sebum production and secretion capacity leads to a blockage of sebum in the hair follicle, followed by inflammation.
  • Hormones continue to affect sebaceous gland activity into adulthood.

Step 2

Step 2

Prevent and remove content build-up in pores

  • The first stage of acne is called comedogenesis (formation of comedones).
  • The exfoliated dead skin cells stick together inside the hair follicle, resulting in a clogged pore or comedone.
  • This is caused by several factors, including increased amounts of sebum, inflammation of the sides of the hair follicle preventing the release of the exfoliated keratinocytes, and increased cohesion of keratinocytes.
  • Salicylic acid decongests pores by dissolving and extracting dirt, oil, and cellular debris (dead skin cells) in the pores and follicles.

Step 3

Step 3

Prevent Bacterial Infiltration and infection

  • The keratinocyte plug and sebum provide excellent food sources for bacteria.
  • The bacteria invade the comedone and release inflammatory factors that lead to the next stage of acne.
  • Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.

Step 4

Step 4

Down-regulate and prevent inflammation

  • Inflammation continues with increased redness and pus.
  • This is clinically detectable as a papule or pustule.
  • Continued inflammation may lead to so much inflammation that the hair follicle ruptures and the bacteria and debris are released into the dermis.
  • Salicylic acid suppresses pro-inflammatory cytokine expression.

Rosacea

Stages and treatment objectives

The skin, microorganisms and the environment constantly interact to maintain a delicate balance. Disturbance of this balance negatively influences both the microflora and skin health.

In Rosacea, the microenvironment of the affected skin is substantially altered, resulting in a shift in the proportion or speciation of the resident microflora. Several microorganisms are increased or immunoreactive if you struggle with rosacea.

Our skin contains pattern recognition receptors (PPR). These receptors detect harmful bacteria on our skin, bind to them, and activate an immune response.

Receptors (PPR) don't activate the immune response for normal micro-flora on our skin. Rosacea-prone skin receptors (PPR) are hyper-reactive and/or have decreased tolerance. They have heightened sensitivity and trigger the inflammatory response of normal microbes, leading to the initial signs of rosacea.

Normal Skin

Normal Skin
  • Healthy skin with a perfect balance between normal microflora and skin receptors.
  • Pathogen-recognizing receptors (PPR) detect and bind to harmful molecules, activating the immune response.
  • These receptors should not trigger an immune response by binding to normal microflora.

Phase 1

Phase 1
  • PPR (receptors) of Rosacea-prone skin bind to normal flora (they are not supposed to) and activate the immune response that causes inflammation.
  • PPR (receptors) of Rosacea-prone skin is hyper-reactive and sensitive. They can be activated by various environmental agents (fragrance, heat, spicy food, etc.)

Phase 2

Phase 2
  • Inflammation leads to an increase in white blood cells (leucocytes) and antimicrobial peptides (cathelicidins), causing certain normal microbes to be eliminated.
  • Disrupting the body's normal microbial community leads to an imbalance, where potentially harmful microbes overgrow and occupy spaces left by the eliminated beneficial microbes.

Phase 3

Phase 3

The negative feedback loop continues: Alterations in the micro-flora lead to increased inflammation, which in turn exacerbates Rosacea, resulting in more severe symptoms.

salicylic acid targets all phases of the acne process