Treatment Pack for Acne, Breakouts and Congested Pores
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Anti-Acne
↓ Sebum
smooth skin
DNA repair
anti-aging
Free Gift with your treatment pack
Cotton Bag
SHIPPING
- Shipping Guarantee: Guiding you to healthy skin isn’t only about our products; it's also about getting them to you as swiftly as the science behind them. That's why Dermal Health offers a shipping guarantee you can rely on.
- Where We Ship From: Orders are dispatched from our facilities in Pretoria.
- Who We Ship With: We trust only well-known, popular, and dependable courier services with your packages.
- When You'll Get It: Expect confident skin soon! Shipping addresses in Pretoria and Johannesburg will enjoy delivery from same-day to 2 business days. Shipping addresses further from Pretoria may expect delivery within 1-4 business days, depending on the service you select during checkout. Your estimated delivery date will reflect during checkout so that you can mark your calendar.
- Tracking Your Order: Eager to start your DermExcel journey? We don't blame you! You'll receive a tracking number after you place your order so that you can follow your package.
For any shipping inquiries, our customer service team is ready to assist.
RETURNS
180-Day Satisfaction Guarantee
Want to log a return? We’ve got you.
You’re welcome to return any product within 180 days of purchase—even if it’s not defective—as long as it’s sealed, unused, in its original packaging, and still within six months of its labeled expiration date (located on the bottom of the product). We get it: sometimes things change.
For non-defective returns, courier costs will be your responsibility.
If you believe a product is defective, please provide a brief explanation so our team can properly assess and process your claim.
Just complete our quick Return Form and we’ll take it from there.
Healthy Skin Isn’t Complicated. Neither Is Our Return Policy.
Visit our Return Policy page or contact our friendly support team if you need assistance.
SECURE PAYMENT
Dermal Health Science 30-Day Confidence Guarantee: We are passionate about guiding you to healthy skin through medical science. We believe in the quality and effectiveness of our products so much that we offer a 30-Day Confidence Guarantee. If you're unsatisfied with your purchase, simply return it within 30 days for a full refund.
Healthy Skin Is Not Complicated and neither is our return policy. Please visit our detailed return policy or contact our friendly customer service team for more information.
Feel as confident in us as we want you to feel in your skin.
MORNING
EVENING
MORNING
EVENING
Morning Regimen Notes
For the best use of Pore Control Cleanser, please check the detailed instructions on its product page. You can access this page by clicking the cleanser's name above.
Apply Inflacin Serum on dry skin every morning after cleansing.
Apply Dermdefence SPF 50 a few minutes after you apply your serum.
Evening Regimen Notes
For the best use of Pore Control Cleanser, please check the detailed instructions on its product page. You can access this page by clicking the cleanser's name above.
Apply Retinol Serum on damp skin in the evening after cleansing.
- After cleansing, apply Salicylic Gel to areas with breakouts and clogged pores 2-3 times per week instead of your serum.
- When breakouts and congested pores have cleared up, apply Salicylic Gel monthly to areas prone to breakouts and congested pores.
- When breakouts and congested pores flare up again, resume treatment with Salicylic Gel.
If you apply Salicylic Gel in the evenings, don't layer it with another product. Other products can make Salicylic Gel less effective by changing its pH.
- Apply Inflacin Serum in the evening after cleansing, wait a few minutes, then layer with Retinol Serum.
- You should not follow the intensified treatment regimen if you have very sensitive skin.
Important Notes
- To allow your skin to adapt, adjust the frequency of the Salicylic Gel to once a week or every two weeks.
- Manually assist with removing loose, flaking skin by gently scrubbing the area/s with your microfibre sponge.
- You should not follow the intensified treatment guidelines if you have sensitive skin.
Dermdefence SPF 50
(Based on your selection)Pore Control Cleanser - 100ml / 175ml
(Depending on the size you selected)Acne-prone skin, characterized by inflammation, redness, and frequent breakouts, demands a targeted and effective approach. Our Acne Treatment Pack is meticulously formulated to reduce inflammation, clear clogged pores, and prevent future breakouts. Consistent use minimizes the appearance of large pores, controls excess oil, and helps maintain a balanced and healthy complexion. Infused with potent anti-inflammatory and antioxidant ingredients, this regimen addresses the root causes of acne and protects your skin from premature aging. By following this comprehensive skincare routine, achieve clearer, healthier skin with a noticeable reduction in breakouts and an improvement in overall skin texture.
your frustrations
- Breakouts, clogged pores, and inflamed skin.
- Oily and shiny skin with enlarged pores.
- Premature skin aging.
- Sensitive skin that reacts to various stimuli and products.
your goals
- Smooth and healthy skin with no breakouts or inflammation.
- Comfortable skin sensations with no itching or other skin discomforts.
- Prevention and correction of premature skin aging, including lines and wrinkles.
- Regulated sebum (oil) production with clear and minimized pores.
hydrated skin
Even Skin Tone
protective barrier
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Natural Hydration: Your oily skin provides a natural layer of hydration, forming a protective barrier against environmental damage. This helps to keep the skin plump and potentially reduces the appearance of fine lines and wrinkles.
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Protective Barrier: The excess sebum can act as a protective barrier against environmental aggressors, potentially reducing the impact of pollutants and other irritants.
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Even Skin Tone: The lack of hyperpigmentation issues means that you enjoy a more consistent and even skin tone.
Acne Breakouts
Oil Management
Congested Pores
Inflammation
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Breakouts and Acne: The propensity for clogged pores can lead to blackheads, whiteheads, and more severe forms of acne, which can be challenging to manage and may lead to scarring or post-inflammatory hyperpigmentation.
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Sebum Control: Controlling excess oil and shine, especially in the T-zone area, can be a constant struggle, affecting the skin's overall appearance.
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Enlarged pores: The excess oil production can lead to enlarged pores and increase the likelihood of blackheads, whiteheads, and acne, which can be challenging to manage alongside aging skin concerns.
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Inflammation: The inflammation associated with breakouts can accelerate skin aging, contribute to wrinkles, and cause skin to lose elasticity over time.
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Product Selection: Identifying skincare and makeup products that address oiliness, prevent and treat breakouts, and tackle aging signs without irritating can be a complex task.
include
- Anti-inflammatory and anti-microbial agents.
- Broad spectrum sunscreen with antioxidants - preventing premature aging and protecting DNA.
- Pigmentation-disrupting ingredients and chemical exfoliating ingredients that accelerate cell turnover and reveal new skin cells.
- Sebum regulating and pore minimizing ingredients.
- Skin identical medical-grade ingredients that penetrate the skin to activate a biological response.
avoid
- Damaging lifestyle habits, e.g., smoking, tanning beds, excessive sun, and sugar consumption.
- Toners and foaming cleansers containing soap & sulfates.
- Fragrance in skincare products.
- Harsh anti-bacterial products that disrupt the skin's natural microbiome.
- Irritating plant extracts and essential oils that will trigger adverse reactions.
Aging . Breakouts
Treatment Objectives
Smooth skin texture
Replace dull and dead skin cells with remodeled skin layers. Resurfacing procedures can induce new collagen formation with a more structured pattern.
Regulate sebum
Balance oil production to minimize shine and reduce the likelihood of congestion and breakouts without stripping the skin of its natural oils.
Unclog pores
Dissolve and extract cellular debris and prevent skin cells from clumping together in pores to ensure that the pores remain clear and free from blockages, which can lead to breakouts.
Clear Acne Breakouts
Reduce and eliminate breakouts by down-regulating the inflammatory response and balancing the skin microbiome.
Prevent & Repair Premature Aging
Protect the skin from factors that accelerate aging, such as UV exposure and pollution, and correct existing signs of aging, like fine lines, wrinkles, and loss of elasticity.
DNA Protection and Repair
Safeguard and repair UV-induced DNA damage, utilizing a blend of UV defense, Retinol, Niacinamide, and antioxidants. This strategy prevents future damage and aids in the repair of existing cellular impairments.
Aging . Breakouts
beneficial active ingredients
Retinoic acid analogue
Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.
Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.
Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.
Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.
Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.
HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.
Physiological Effects
- Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
- Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
- Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
- Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
- Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
- Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
Special Benefits
- Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
- Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
- Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
- Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
- Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.
References
- Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
- Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
- Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
- Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
- Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
Aloe Vera
Aloe vera is well-regarded for its medicinal applications and has been a staple in skincare and health for centuries. It’s rich in vitamins, enzymes, minerals, and amino acids, contributing to its many skin benefits.
Aloe vera contains polysaccharides, which are crucial in its moisturizing and anti-inflammatory properties. These polysaccharides help bind moisture to the skin, making aloe vera an excellent hydrating agent for dry and damaged skin.
One of the key benefits of aloe vera is its soothing and healing properties, particularly beneficial for burns, abrasions, and skin irritations. It has been shown to accelerate the healing of minor burns and reduce skin inflammation. Various studies have supported its effectiveness in treating first- and second-degree burns, highlighting its role in enhancing collagen synthesis and skin regeneration.
Aloe vera's anti-inflammatory properties are attributed to compounds like glycoproteins and polysaccharides. These compounds help reduce pain and swelling associated with skin irritations and wounds. Aloe vera also contains aloin and emodin, which provide analgesic, antibacterial, and antiviral properties, further extending its therapeutic potential.
Aloe Vera has numerous physiological effects on the skin due to its rich composition of vitamins, enzymes, minerals, and amino acids. The presence of antioxidants such as vitamins C and E, along with beta-carotene, contributes to its anti-aging benefits, helping to improve skin firmness and keep the skin hydrated.
Physiological Effects
- Moisturizing and Hydrating: Aloe Vera enhances skin hydration, making it effective for dry and dehydrated skin. Its mucopolysaccharides help to bind moisture into the skin.
- Wound Healing: It accelerates wound healing by enhancing collagen synthesis and cross-linking. This effect is particularly useful in healing burns, abrasions, and cuts.
- Anti-inflammatory Properties: Aloe Vera contains compounds like aloin and anthraquinones that have anti-inflammatory properties, making it beneficial in reducing skin inflammation.
- Antimicrobial Activity: It possesses antimicrobial properties, which help in preventing infections in wounds and burns.
- Antioxidant Properties: The presence of vitamins C and E and beta-carotene provides it with antioxidant properties, which can help protect the skin from free radical damage.
- Soothing Effect: Aloe Vera is known for its soothing effects on the skin, particularly in conditions like sunburn.
Managing Dermatological Conditions
- Burns and Wound Care: Aloe Vera's wound-healing and soothing properties make it effective in treating burns, including sunburns and minor skin abrasions.
- Acne Treatment: Due to its antimicrobial and anti-inflammatory properties, it can help treat acne.
- Eczema and Psoriasis: Its moisturizing, anti-inflammatory, and soothing properties are beneficial in managing symptoms of eczema and psoriasis.
- Aging Skin: Aloe Vera's antioxidant properties and ability to improve collagen production can help reduce the signs of aging.
- Skin Hydration: It's a common ingredient in moisturizers and other skin care products for its hydrating properties.
References
- Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian Journal of Dermatology.
- Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., & Kongkaew, C. (2007). The efficacy of aloe vera used for burn wound healing: A systematic review. Burns.
- Rajeswari, R., Umadevi, M., Rahale, C. S., Pushpa, R., Selvavenkadesh, S., Kumar, K. S., & Bhowmik, D. (2012). Aloe vera: The miracle plant its medicinal and traditional uses in India. Journal of Pharmacognosy and Phytochemistry.
Niacinamide
Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.
Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.
Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.
The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Physiological Effects
- Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
- Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
- Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
- Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
- Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
- Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Managing Dermatological Conditions
- Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
- Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
- Aging Skin: Niacinamide targets wrinkles and loss of firmness.
- Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
- Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.
References
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
- Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
- Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Salicylic acid
Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. It uniquely penetrates oil-laden hair follicle pores, making it particularly effective in treating acne-prone and oily skin types.
Salicylic acid works by dissolving skin debris that clogs pores and causes acne, namely sebum and dead skin cells. It's a mild anti-bacterial- and a powerful anti-inflammatory agent, which helps to reduce the redness and swelling associated with breakouts.
What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.
Furthermore, salicylic acid also can adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.
Physiological Effects
- Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together. This helps remove dead skin cells and unclog pores.
- Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
- Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
- Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
- Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.
Managing Dermatological Conditions
- Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
- Psoriasis: Its keratolytic properties effectively soften and remove scales associated with psoriasis.
- Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
- Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
- Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.
References
- Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
- Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
- Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Zinc PCA
Zinc PCA, also known as Zinc Pyrrolidone Carboxylic Acid, is a skin care ingredient that combines the mineral zinc with a hydrating molecule PCA (Pyrrolidone Carboxylic Acid). It is renowned for its numerous benefits in skincare, particularly for its anti-inflammatory, antimicrobial, and sebum-regulating properties.
Zinc PCA is derived from zinc, an essential mineral known for its antioxidant and skin-soothing capabilities. Zinc is also noted for its role in wound healing and its ability to reduce inflammation, which can be particularly beneficial for acne-prone and irritated skin. The PCA component is a natural moisturizing factor (NMF) found in the skin, which helps maintain the skin's hydration levels.
One of the key benefits of Zinc PCA is its ability to regulate sebum production. Excess sebum can lead to acne and oily skin, and Zinc PCA helps to moderate this by inhibiting the activity of the enzyme 5-alpha reductase, which is involved in oil production. This makes it an effective ingredient in formulations targeting oily and acne-prone skin (Schueller, R. and Romanowski, P., 2003).
In addition to its sebum-regulating properties, Zinc PCA possesses antimicrobial properties, which further contribute to its efficacy in treating acne. By reducing the presence of acne-causing bacteria on the skin, it helps to prevent and reduce acne breakouts.
Moreover, Zinc PCA's anti-inflammatory properties make it beneficial for soothing irritated skin and reducing redness and inflammation associated with various skin conditions, including acne, rosacea, and eczema.
Physiological Effects
- Sebum Regulation: Zinc PCA reduce and regulate sebum secretion and production, making it beneficial for oily and acne-prone skin by controlling excess oil production.
- Antimicrobial Action: Zinc has antimicrobial properties, particularly effective against acne-causing bacteria, reducing acne breakouts.
- Anti-inflammatory Effects: Zinc PCA reduces inflammation, which is beneficial in treating inflammatory skin conditions like acne and rosacea.
- Moisture Retention: PCA is a natural moisturizing factor (NMF) that helps maintain skin hydration, enhancing the skin’s moisture retention capabilities.
- Wound Healing: Zinc is essential for wound healing processes, aiding in the repair and regeneration of skin tissues.
Managing Dermatological Conditions
- Acne Management: Its ability to regulate sebum production and provide antimicrobial action makes Zinc PCA a valuable ingredient in acne treatments.
- Oily Skin: It's beneficial in controlling excess oiliness and maintaining a balanced skin environment.
- Sensitive Skin Conditions: Due to its anti-inflammatory properties, Zinc PCA soothes sensitive skin and conditions like rosacea.
- Skin Hydration: Its role as an NMF helps in maintaining skin hydration, useful in treating dry skin conditions.
References
- Schagen, S. K., et al. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology.
- Firooz, A., et al. (2011). Zinc therapy in dermatology: a review. Dermatology Research and Practice.
- Gupta, M., et al. (2014). Zinc therapy in dermatology. Indian Dermatology Online Journal.
- Schueller, R. and Romanowski, P. (2003). Conditioning Agents for Hair and Skin. Cosmetic Science and Technology Series. Marcel Dekker Inc., New York, USA.
Matrixyl 3000
Matrixyl 3000: The Powerhouse of Anti-Aging Peptides
Matrixyl 3000, a trademarked peptide composition, has revolutionized the approach towards anti-aging in dermatological products. This innovative ingredient combines two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. The synergy of these peptides enhances skin repair and reduces the appearance of aging.
Physiological Effects
- Collagen and Elastin Stimulation: Matrixyl 3000 promotes the production of collagen and elastin, key proteins that provide skin structure and elasticity. This helps reduce the appearance of fine lines and wrinkles.
- Skin Repair and Regeneration: It aids in the skin's repair process, enhancing the overall texture and tone, and may help reverse the signs of aging.
- Anti-inflammatory Properties: Matrixyl 3000 can have anti-inflammatory effects, reducing inflammation and potentially aiding in skin repair.
- Hydration Enhancement: Improving the underlying skin structure can enhance hydration, leading to a plumper, more youthful appearance.
Managing Dermatological Conditions
- Aging Skin: Its primary use is in anti-aging skincare products to combat wrinkles, fine lines, and other signs of aging.
- Improving Skin Texture and Tone: Matrixyl 3000 can improve overall skin texture, which is beneficial for skin that has lost smoothness or become rough due to aging.
- Skin Elasticity: It can help improve skin elasticity, making it appear firmer and more toned.
Biochemical Mechanism and Clinical Efficacy
Matrixyl 3000 mimics the appearance of broken-down collagen, causing the skin to react by producing more collagen and elastin. Palmitoyl Tripeptide-1 is known for stimulating collagen synthesis and firming the skin, while Palmitoyl Tetrapeptide-7 reduces inflammation, a key contributor to aging.
Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).
Matrixyl 3000 stands out as a non-irritating, highly effective ingredient. Its role in stimulating collagen and elastin production and reducing inflammation is a cornerstone in anti-aging skincare regimens.
References
- Smith, J. (2005). "Effects of Matrixyl 3000 on Skin Aging." International Journal of Cosmetic Science.
- Sederma Inc., "Matrixyl 3000 Technical Overview."
- Blackburn, R. S., et al. (2005). Matrixyl 3000 restores skin's metabolic balance. Journal of Cosmetic Science.
- Lintner, K., et al. (2007). Matrixyl 3000: A new approach to anti-aging. Personal Care Magazine.
- Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
Acetyl Hexapeptide-8
Acetyl Hexapeptide-8: The Innovative Peptide in Anti-Aging Dermatology
Acetyl Hexapeptide-8 is a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.
Biochemical Mechanism
Acetyl Hexapeptide-8 functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.
Physiological Effects
- Neurotransmitter Inhibition: Acetyl Hexapeptide-8 works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
- Reduction of Expression Lines: Helps to reduce the appearance of expression lines, particularly around the forehead and eyes, by limiting muscle contraction.
- Improvement in Skin Texture: Regular use can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.
Special Benefits
Clinical Efficacy - Clinical studies have demonstrated the effectiveness of Acetyl Hexapeptide-8 in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Acetyl Hexapeptide-8 reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).
References
- Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
- Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
- Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.
Vitamin E
The fat-soluble Vitamin E's benefits in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.
Vitamin E is celebrated in skincare for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.
Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reduce moisture loss, and keep the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.
Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.
Physiological Effects
- Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
- Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
- Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
- Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
- Anti-Inflammatory Effects: It helps reduce skin inflammation and is beneficial in managing conditions like eczema and psoriasis.
Managing Dermatological Conditions
- Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
- Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
- Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
- Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
- Scar Treatment: Some studies suggest Vitamin E may help reduce the appearance of scars, although evidence is mixed.
References
- Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
- Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
- Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
- Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
- Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.
Coenzyme Q10
CoQ10 is a potent ingredient that offers comprehensive skin health and appearance benefits. Its role in energy production and its antioxidant and anti-aging properties make it invaluable for photoprotection, anti-aging, and overall skin vitality. Its incorporation into DermExcel sunscreen represents a holistic approach to skin health, addressing protective and restorative needs.
Physiological Impact
- Skin Barrier Enhancement: CoQ10 contributes to the strength and health of the skin barrier, improving its ability to retain moisture and protect against external irritants and pollutants.
- Skin Repair and Regeneration: It supports the skin's natural ability to repair itself and regenerate, maintaining a healthy, youthful appearance. This is particularly beneficial in mature skin, where natural levels of CoQ10 may be depleted.
Pharmacological Advantages
- Anti-Aging Effects: CoQ10's antioxidant properties contribute to its anti-aging effects. By reducing oxidative stress, it helps to minimize the visible signs of aging, such as wrinkles and fine lines.
- Photoprotection: It enhances the skin's defense against photoaging caused by exposure to UV rays. CoQ10 helps to mitigate the degradation of collagen and elastin, proteins essential for maintaining skin elasticity and firmness.
Biochemical Benefits
- Cellular Energy Production: CoQ10 plays a crucial role in the mitochondrial electron transport chain, which is essential for the production of ATP, the primary energy currency of the cell. This function is vital for maintaining the health and vitality of skin cells.
- Antioxidant Properties: It acts as a lipophilic antioxidant, neutralizing free radicals and preventing oxidative damage to cell membranes, proteins, and DNA. This is particularly important in the skin, which is frequently exposed to oxidative stress from environmental factors like UV radiation.
Sunscreen
Using sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential for reducing the risk of skin cancers and photoaging and maintaining overall skin health in the face of constant exposure to UV radiation.
Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. Two primary types of UV radiation affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.
Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.
The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means it would take 30 times longer for your skin to burn than without sunscreen. However, it's important to note that no sunscreen can block 100% UV rays.
Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.
Managing Dermatological Conditions
- Prevention of Sunburn: Sunscreen protects the skin from UVB rays, which cause sunburn. This reduces the immediate risk of skin damage and discomfort.
- Skin Cancer Prevention: Regular use of sunscreen significantly lowers the risk of developing various types of skin cancer, especially melanoma, squamous cell carcinoma, and basal cell carcinoma.
- Prevention of Photoaging: Sunscreen also shields the skin from UVA rays, which penetrate deeper into the skin and are primarily responsible for photoaging, including wrinkles, leathery skin, and sunspots.
- Protection Against Photosensitivity: Sunscreen helps prevent flare-ups triggered by sun exposure for individuals with photosensitive skin conditions like lupus or rosacea.
- Hyperpigmentation and Melasma: It aids in preventing and managing hyperpigmentation and melasma, conditions exacerbated by sun exposure.
- General Skin Health: Sunscreen helps maintain overall skin health and integrity by protecting the skin from UV damage.
References
- Burnett, M. E., & Wang, S. Q. (2011). Current sunscreen controversies: a critical review. Photodermatology, Photoimmunology & Photomedicine.
- Green, A. C., et al. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology.
- Hughes, M. C. B., et al. (2013). Sunscreen and Prevention of Skin Aging: A Randomized Trial. Annals of Internal Medicine.
Aging . Breakouts
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Unclog Pores
Minimize Pores
Anti-Acne
anti-redness
↓ inflammation
This scientifically formulated skincare solution regulates sebum production, thereby mitigating pore congestion. It employs a 3% concentration of Salicylic acid, a renowned anti-inflammatory agent, which diligently alleviates skin irritation and redness. This ingredient is also known for its potent anti-bacterial properties, effectively cleansing the skin of stubborn impurities.
A distinguishing feature of this cleanser is its inclusion of medical-grade Aloe Vera, a natural ingredient revered for its skin-nourishing capabilities. Aloe Vera imparts soothing and hydrating effects, particularly beneficial for skin dehydration due to other acne treatments.
Pore Control Cleanser is a balanced blend of scientifically proven ingredients that synergistically maintain skin health. It normalizes oil production, dislodges sebum plugs, reduces inflammation, and nourishes the skin, making it a comprehensive solution for maintaining a clear and healthy complexion.
Salicylic acid
Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.
Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.
What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.
Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.
Physiological Effects
- Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
- Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
- Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
- Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
- Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.
Managing Dermatological Conditions
- Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
- Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
- Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
- Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
- Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with peratosis Pilaris.
References
- Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
- Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
- Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Aloe Vera
Aloe vera is well-regarded for its medicinal applications and has been a staple in skincare and health for centuries. It’s rich in vitamins, enzymes, minerals, and amino acids, contributing to its many skin benefits.
Aloe vera contains polysaccharides, which are crucial in its moisturizing and anti-inflammatory properties. These polysaccharides help bind moisture to the skin, making aloe vera an excellent hydrating agent for dry and damaged skin.
One of the key benefits of aloe vera is its soothing and healing properties, particularly beneficial for burns, abrasions, and skin irritations. It has been shown to accelerate the healing of minor burns and reduce skin inflammation. Various studies have supported its effectiveness in treating first- and second-degree burns, highlighting its role in enhancing collagen synthesis and skin regeneration.
Aloe vera's anti-inflammatory properties are attributed to compounds like glycoproteins and polysaccharides. These compounds help reduce pain and swelling associated with skin irritations and wounds. Aloe vera also contains aloin and emodin, which provide analgesic, antibacterial, and antiviral properties, further extending its therapeutic potential.
Aloe Vera has numerous physiological effects on the skin due to its rich composition of vitamins, enzymes, minerals, and amino acids. The presence of antioxidants such as vitamins C and E, along with beta-carotene, contributes to its anti-aging benefits, helping to improve skin firmness and keep the skin hydrated.
Physiological Effects
- Moisturizing and Hydrating: Aloe Vera enhances skin hydration, making it effective for dry and dehydrated skin. Its mucopolysaccharides help to bind moisture into the skin.
- Wound Healing: It accelerates wound healing by enhancing collagen synthesis and cross-linking. This effect is particularly useful in healing burns, abrasions, and cuts.
- Anti-inflammatory Properties: Aloe Vera contains compounds like aloin and anthraquinones that have anti-inflammatory properties, making it beneficial in reducing skin inflammation.
- Antimicrobial Activity: It possesses antimicrobial properties, which help in preventing infections in wounds and burns.
- Antioxidant Properties: The presence of vitamins C and E and beta-carotene provides it with antioxidant properties, which can help protect the skin from free radical damage.
- Soothing Effect: Aloe Vera is known for its soothing effects on the skin, particularly in conditions like sunburn.
Managing Dermatological Conditions
- Burns and Wound Care: Aloe Vera's wound-healing and soothing properties make it effective in treating burns, including sunburns and minor skin abrasions.
- Acne Treatment: Due to its antimicrobial and anti-inflammatory properties, it can help treat acne.
- Eczema and Psoriasis: Its moisturizing, anti-inflammatory, and soothing properties are beneficial in managing symptoms of eczema and psoriasis.
- Aging Skin: Aloe Vera's antioxidant properties and ability to improve collagen production can help reduce the signs of aging.
- Skin Hydration: It's a common ingredient in moisturizers and other skin care products for its hydrating properties.
References
- Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian Journal of Dermatology.
- Maenthaisong, R., Chaiyakunapruk, N., Niruntraporn, S., & Kongkaew, C. (2007). The efficacy of aloe vera used for burn wound healing: A systematic review. Burns.
- Rajeswari, R., Umadevi, M., Rahale, C. S., Pushpa, R., Selvavenkadesh, S., Kumar, K. S., & Bhowmik, D. (2012). Aloe vera: The miracle plant its medicinal and traditional uses in India. Journal of Pharmacognosy and Phytochemistry.
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Unclog Pores
↓ Sebum
Anti-Acne
↓ inflammation
anti-aging
A medical-grade treatment with a potent blend of anti-inflammatory and acne-combating ingredients to address skin issues in oily, acne-prone, and combination skin types. The formulation prioritizes preserving skin hydration while eliminating skin concerns like pimples and blackheads.
The serum's composition includes salicylic acid, known for its proficiency in unclogging pores and reducing acne-related inflammation. Zinc PCA is critical in regulating sebum production and minimizing oily skin complications. Niacinamide shrinks enlarged pores and alleviates inflammation related to acne and rosacea. Lastly, retinol stimulates cell turnover, aids in the fight against premature aging, and enhances overall skin texture and tone.
As a holistic approach, Inflacin Serum reduces current skin issues and aims to prevent future skin complications, thus promoting a healthier skin condition.
Niacinamide
Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.
Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.
Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.
The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Physiological Effects
- Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
- Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
- Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
- Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
- Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
- Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Managing Dermatological Conditions
- Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
- Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
- Aging Skin: Niacinamide targets wrinkles and loss of firmness.
- Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
- Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.
References
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
- Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
- Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Salicylic acid
Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.
Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.
What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.
Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.
Physiological Effects
- Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
- Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
- Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
- Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
- Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.
Managing Dermatological Conditions
- Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
- Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
- Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove thick skin.
- Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
- Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with peratosis Pilaris.
References
- Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
- Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
- Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
Zinc PCA
Zinc PCA, also known as Zinc Pyrrolidone Carboxylic Acid, is a skin care ingredient that combines the mineral zinc with a hydrating molecule PCA (Pyrrolidone Carboxylic Acid). It is renowned for its numerous benefits in skincare, particularly for its anti-inflammatory, antimicrobial, and sebum-regulating properties.
Zinc PCA is derived from zinc, an essential mineral known for its antioxidant and skin-soothing capabilities. Zinc is also noted for its role in wound healing and its ability to reduce inflammation, which can be particularly beneficial for acne-prone and irritated skin. The PCA component is a natural moisturizing factor (NMF) found in the skin, which helps maintain the skin's hydration levels.
One of the key benefits of Zinc PCA is its ability to regulate sebum production. Excess sebum can lead to acne and oily skin, and Zinc PCA helps to moderate this by inhibiting the activity of the enzyme 5-alpha reductase, which is involved in oil production. This makes it an effective ingredient in formulations targeting oily and acne-prone skin (Schueller, R. and Romanowski, P., 2003).
In addition to its sebum-regulating properties, Zinc PCA possesses antimicrobial properties, which further contribute to its efficacy in treating acne. By reducing the presence of acne-causing bacteria on the skin, it helps to prevent and reduce acne breakouts.
Moreover, Zinc PCA's anti-inflammatory properties make it beneficial for soothing irritated skin and reducing redness and inflammation associated with various skin conditions, including acne, rosacea, and eczema.
Physiological Effects
- Sebum Regulation: Zinc PCA reduce and regulate sebum secretion and production, making it beneficial for oily and acne-prone skin by controlling excess oil production.
- Antimicrobial Action: Zinc has antimicrobial properties, particularly effective against acne-causing bacteria, reducing acne breakouts.
- Anti-inflammatory Effects: Zinc PCA reduces inflammation, which is beneficial in treating inflammatory skin conditions like acne and rosacea.
- Moisture Retention: PCA is a natural moisturizing factor (NMF) that helps maintain skin hydration, enhancing the skin’s moisture retention capabilities.
- Wound Healing: Zinc is essential for wound healing processes, aiding in the repair and regeneration of skin tissues.
Managing Dermatological Conditions
- Acne Management: Its ability to regulate sebum production and provide antimicrobial action makes Zinc PCA a valuable ingredient in acne treatments.
- Oily Skin: It's beneficial in controlling excess oiliness and maintaining a balanced skin environment.
- Sensitive Skin Conditions: Due to its anti-inflammatory properties, Zinc PCA soothes sensitive skin and conditions like rosacea.
- Skin Hydration: Its role as an NMF helps in maintaining skin hydration, useful in treating dry skin conditions.
References
- Schagen, S. K., et al. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology.
- Firooz, A., et al. (2011). Zinc therapy in dermatology: a review. Dermatology Research and Practice.
- Gupta, M., et al. (2014). Zinc therapy in dermatology. Indian Dermatology Online Journal.
- Schueller, R. and Romanowski, P. (2003). Conditioning Agents for Hair and Skin. Cosmetic Science and Technology Series. Marcel Dekker Inc., New York, USA.
Retinoic acid analogue
Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.
Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.
Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.
Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.
Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.
HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.
Physiological Effects
- Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
- Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
- Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
- Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
- Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
- Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
Special Benefits
- Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
- Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
- Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
- Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
- Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.
References
- Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
- Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
- Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
- Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
- Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
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Unclog Pores
Minimize Pores
Smooth Skin
anti-aging
DNA repair
An advanced skincare formula that leverages the potency of active ingredients like Hydroxypinacolone Retinoate, Niacinamide, and Acetyl Hexapeptide-8.
Hydroxypinacolone Retinoate, a form of retinoid, works at the cellular level to stimulate epidermal growth, counteracting both intrinsic and extrinsic signs of aging. It aids in reducing hyperpigmentation and evening skin tone while promoting the development of collagen and elastin, proteins that are vital for maintaining skin's elasticity and structure.
Another key ingredient, Niacinamide, is instrumental in supporting cell health in the skin. It helps build and protect skin cells from environmental stresses like sunlight, pollution, and toxins while also significantly supporting acne treatment.
Acetyl Hexapeptide-8, a synthetic peptide, adds to the formula's efficacy by slowing down muscle movement in the face, thus decreasing the appearance of wrinkles and expression lines. It enhances collagen production, which firms the skin and increases its elasticity. Additionally, it provides hydration, keeping the skin well-moisturized.
DermExcel Retinol Serum stimulates collagen production, reduces inflammation, inhibits pigmentation, and accelerates cell turnover, all contributing to a healthier and more youthful complexion. It also aids in reducing sebum production and unclogging pores, making it a potent tool in the battle against acne.
Retinoic acid analogue
Retinoic acid, often referred to as tretinoin in its pharmaceutical form, is the active form of Vitamin A. It is widely recognized for its powerful effects in dermatology and skin care, particularly in treating acne and signs of skin aging.
Retinoic acid works at the cellular level to modify gene expression and affect cell growth. In treating acne, it promotes the turnover of skin cells, reducing the likelihood of pore-clogging and helping to clear existing breakouts. Additionally, it decreases the cohesiveness of follicular epithelial cells, further preventing the formation of comedones.
Retinoic acid's ability to stimulate collagen production is a key benefit in anti-aging skincare. This leads to a reduction in fine lines and wrinkles and an improvement in overall skin texture and tone. It also aids skin discoloration and hyperpigmentation by accelerating cell turnover, bringing new skin cells to the surface faster, and shedding pigmented and damaged cells.
Despite its benefits, retinoic acid can irritate the skin, causing side effects like redness, dryness, and peeling, especially during the initial period of use. Its potency means it is generally available by prescription and requires careful monitoring by a healthcare professional.
Hydroxypinacolone Retinoate (HPR) is a newer, esterified form of retinoic acid. Unlike cosmetic retinol, HPR binds directly to the retinoid receptors of the skin cells without needing conversion. This direct binding allows it to deliver similar benefits to retinoic acid, such as stimulating collagen production, improving skin elasticity, and reducing signs of aging, but with a lower risk of irritation.
HPR is considered more gentle and less irritating than traditional retinoic acid while offering comparable benefits. With HPR, everyone has access to the benefits of prescription retinoids without the risk of side effects.
Physiological Effects
- Cell Turnover and Renewal: HPR promotes rapid cell turnover, aiding in the exfoliation of dead skin cells and generating new cells.
- Skin Texture: Promoting cell renewal improves skin texture and addresses issues like roughness and dullness.
- Collagen Production: It stimulates collagen production, which is essential for reducing the appearance of fine lines and wrinkles and improving skin elasticity.
- Acne Treatment: Effective in treating acne by unclogging pores and reducing the size of sebaceous glands, it diminishes both inflammatory and non-inflammatory acne lesions.
- Pigmentation: It can reduce hyperpigmentation by accelerating the turnover of hyperpigmented skin cells and inhibiting melanin production.
- Photoaging: Effective in treating signs of photoaging, reversing some of the damage caused by UV radiation.
Special Benefits
- Retinoid Receptor Activity: HPR, an ester of retinoic acid, binds directly to retinoid receptors in the skin, enabling it to work without needing to be converted into retinoic acid.
- Lower Irritation: Typically, it causes less irritation than retinoic acid, making it more suitable for sensitive skin types.
- Collagen Stimulation and Anti-Aging: Like retinoic acid, HPR helps in stimulating collagen production and has anti-aging properties.
- Acne and Hyperpigmentation: It effectively treats acne and reduces hyperpigmentation, often with fewer side effects than retinoic acid.
- Stability and Penetration: HPR is more stable and lipid-soluble, so it penetrates the skin more effectively and is less prone to degradation.
References
- Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., ... & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
- Fisher, G. J., Wang, Z. Q., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1996). Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine, 337(20), 1419-1428.
- Truchuelo, M. T., Jiménez, N., Jaén, P. (2018). Assessment of the efficacy of a new complex-based retinoic acid and retinol in a 3-month study using objective methods and skin biomarker analysis. Journal of Cosmetic Dermatology, 17(3), 347-354.
- Mukherjee, S., et al. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging.
- Randhawa, M., et al. (2015). Hydroxypinacolone retinoate: a new retinoid and its use in dermatology. Skin Therapy Letter.
Niacinamide
Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.
Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.
Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.
The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Physiological Effects
- Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
- Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
- Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
- Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
- Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
- Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Managing Dermatological Conditions
- Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
- Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
- Aging Skin: Niacinamide targets wrinkles and loss of firmness.
- Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
- Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.
References
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
- Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
- Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Peptides
Peptides are short chains of amino acids with a wide range of biological functions and skin benefits. They are essentially small fragments of proteins, which are fundamental components of all living cells, including collagen and elastin in the skin.
In skincare, peptides are known for enhancing skin repair and rejuvenation. They function as signaling molecules, instructing cells to perform specific tasks such as producing collagen and elastin, vital for maintaining the skin's firmness and elasticity. This makes peptides especially beneficial in anti-aging products, as they can help reduce the appearance of fine lines and wrinkles.
Research has shown that certain peptides can improve skin barrier function, increase hydration, and soothe skin inflammation. This makes them suitable for products targeting dry, sensitive, or inflamed skin.
Peptides, with their diverse functions in promoting collagen production, strengthening the skin barrier, wound healing, and anti-inflammatory actions, are pivotal in managing various dermatological conditions, particularly in anti-aging, sensitive skin care, and wound healing applications.
Physiological Effects
- Collagen Production: Certain peptides, known as signal peptides, stimulate collagen production in the skin, enhancing skin firmness and reducing the appearance of fine lines and wrinkles.
- Skin Barrier Strengthening: Peptides can strengthen the skin barrier, improve hydration, and protect against environmental damage.
- Wound Healing: Some peptides play a role in the skin's natural healing process, aiding tissue repair and regeneration.
- Anti-Inflammatory Effects: Certain peptides have anti-inflammatory properties, helping to soothe and calm irritated skin.
- Antimicrobial Action: Some peptides possess antimicrobial properties, potentially helping to manage acne and other skin infections.
Managing Dermatological Conditions
- Aging Skin: Peptides can stimulate collagen production and improve skin elasticity.
- Sensitive Skin Conditions: Peptides are beneficial for sensitive or inflamed skin due to their soothing properties.
- Acne-Prone Skin: Antimicrobial peptides can be effective in acne treatment formulations.
- Wound Care and Repair: Peptides improve wound healing and reduce scarring.
References
- Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
- Schagen, S. K. (2012). Topical peptide treatments with effective anti-aging results. Cosmetics.
- Varani, J., et al. (2001). Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. Journal of Investigative Dermatology.
Matrixyl 3000
Matrixyl 3000: The Powerhouse of Anti-Aging Peptides
Matrixyl 3000, a trademarked peptide composition, has revolutionized the approach towards anti-aging in dermatological products. This innovative ingredient combines two peptides, Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7. The synergy of these peptides enhances skin repair and reduces the appearance of aging.
Physiological Effects
- Collagen and Elastin Stimulation: Matrixyl 3000 promotes the production of collagen and elastin, key proteins that provide skin structure and elasticity. This helps reduce the appearance of fine lines and wrinkles.
- Skin Repair and Regeneration: It aids in the skin's repair process, enhancing the overall texture and tone, and may help reverse the signs of aging.
- Anti-inflammatory Properties: Matrixyl 3000 can have anti-inflammatory effects, reducing inflammation and potentially aiding in skin repair.
- Hydration Enhancement: Improving the underlying skin structure can enhance hydration, leading to a plumper, more youthful appearance.
Managing Dermatological Conditions
- Aging Skin: Its primary use is in anti-aging skincare products to combat wrinkles, fine lines, and other signs of aging.
- Improving Skin Texture and Tone: Matrixyl 3000 can improve overall skin texture, which is beneficial for skin that has lost smoothness or become rough due to aging.
- Skin Elasticity: It can help improve skin elasticity, making it appear firmer and more toned.
Biochemical Mechanism and Clinical Efficacy
Matrixyl 3000 mimics the appearance of broken-down collagen, causing the skin to react by producing more collagen and elastin. Palmitoyl Tripeptide-1 is known for stimulating collagen synthesis and firming the skin, while Palmitoyl Tetrapeptide-7 reduces inflammation, a key contributor to aging.
Studies have shown that Matrixyl 3000 significantly improves skin elasticity and reduces wrinkle depth. A notable study published in the "International Journal of Cosmetic Science" demonstrated that Matrixyl 3000 reduced wrinkle volume and depth by up to 45% after 2 months of use (Smith, 2005).
Matrixyl 3000 stands out as a non-irritating, highly effective ingredient. Its role in stimulating collagen and elastin production and reducing inflammation is a cornerstone in anti-aging skincare regimens.
References
- Smith, J. (2005). "Effects of Matrixyl 3000 on Skin Aging." International Journal of Cosmetic Science.
- Sederma Inc., "Matrixyl 3000 Technical Overview."
- Blackburn, R. S., et al. (2005). Matrixyl 3000 restores skin's metabolic balance. Journal of Cosmetic Science.
- Lintner, K., et al. (2007). Matrixyl 3000: A new approach to anti-aging. Personal Care Magazine.
- Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science.
Acetyl Hexapeptide-8
Acetyl Hexapeptide-8: The Innovative Peptide in Anti-Aging Dermatology
Acetyl Hexapeptide-8 is a testament to the advancements in peptide technology in dermatology. Its ability to reduce facial muscle contractions non-invasively positions it as an essential ingredient in anti-aging skincare.
Biochemical Mechanism
Acetyl Hexapeptide-8 functions by inhibiting the neurotransmitters that trigger muscle contractions. This action reduces the intensity of wrinkle-causing facial expressions, leading to a visible decrease in fine lines and wrinkles. It mimics the N-terminal end of SNAP-25, competing with this natural protein for a position in the SNARE complex, thereby destabilizing it. As a result, neurotransmitter release is diminished, and facial muscle contractions are softened.
Physiological Effects
- Neurotransmitter Inhibition: Acetyl Hexapeptide-8 works by inhibiting neurotransmitter release. This leads to reduced facial muscle contraction, a mechanism similar to Botox but less invasive.
- Reduction of Expression Lines: Helps to reduce the appearance of expression lines, particularly around the forehead and eyes, by limiting muscle contraction.
- Improvement in Skin Texture: Regular use can lead to smoother skin texture and a reduction in the depth and severity of wrinkles.
Special Benefits
Clinical Efficacy - Clinical studies have demonstrated the effectiveness of Acetyl Hexapeptide-8 in reducing wrinkle depth. A study published in the "International Journal of Cosmetic Science" reported that a cream containing 10% Acetyl Hexapeptide-8 reduced wrinkles by 30% over 30 days (Blanes-Mira et al., 2002).
References
- Blanes-Mira, C., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science.
- Wang, Y., et al. (2013). The anti-wrinkle efficacy of Argireline. Journal of Cosmetic and Laser Therapy.
- Ruiz, M. A., et al. (2007). New cosmetic formulations containing Argireline. Journal of Cosmetic Science.
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loginSIZE: 30 mL
↓ Sebum
Unclog Pores
Anti-Acne
↓ inflammation
Ingrown hair
Salicylic Gel is a scientifically formulated chemical exfoliating treatment enriched with 5% Salicylic acid, renowned for its potent anti-inflammatory, oil-regulating, and cell-resurfacing properties. This advanced gel is meticulously designed to combat acne and folliculitis by effectively inhibiting the growth of acne-causing bacteria. It efficiently reduces irritation and inflammation associated with these conditions, relieving troubled skin.
With its optimal concentration of Salicylic acid, Salicylic Gel clears existing acne and folliculitis lesions, promoting a smoother and healthier complexion. By gently exfoliating the skin's surface, it aids in cell turnover, diminishing the appearance of blemishes and scars over time.
Featuring its primary active ingredient, Salicylic acid, this targeted gel provides a safe and reliable solution to tackle breakouts effectively. Regulating the skin's sebum production helps prevent future breakouts, addressing the root cause of acne and folliculitis. Salicylic Gel is a valuable addition to any skincare routine, particularly for those seeking a scientifically backed solution to troublesome skin conditions.
Salicylic acid
Salicylic acid, a renowned beta hydroxy acid (BHA), is a cornerstone in dermatology and skincare due to its exceptional keratolytic and comedolytic properties. Its unique ability to penetrate oil-laden hair follicle pores makes it particularly effective in treating acne-prone and oily skin types.
Salicylic acid dissolves skin debris (sebum and dead skin cells) that clogs pores and causes acne. It's a mild antibacterial and powerful anti-inflammatory agent that helps reduce the redness and swelling associated with breakouts.
What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin, not just on the surface but within the pores themselves. This is due to its oil-soluble nature, which allows it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.
Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions in terms of count and severity. Additionally, Salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.
Physiological Effects
- Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
- Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
- Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
- Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
- Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, effectively treating acne located deep within the pores.
Managing Dermatological Conditions
- Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effectively preventing and treating existing acne lesions.
- Psoriasis: Its keratolytic properties make it helpful in softening and removing scales associated with psoriasis.
- Warts: Salicylic acid is commonly used to treat warts because it can exfoliate and remove the thickened skin.
- Seborrheic Dermatitis: It helps manage seborrheic dermatitis by reducing scaling and redness.
- Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.
References
- Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
- Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
- Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.
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loginSIZE: 50 mL
Antioxidant
anti-aging
DNA repair
sun protection
Moisturizing
A pioneering sunscreen offering superior protection against the sun while preserving your skin's cellular and DNA health. The innovative formula exceeds standard UV protection, guarding against UVA, UVB, damaging infrared rays, and blue light. Offering wide-ranging protection bolsters your skin's restorative abilities, promoting a healthier and more resilient complexion.
Designed to be fragrance-free and anti-comedogenic, Dermdefence SPF 50 ensures no skin irritation or pore clogging, making it an excellent choice for those with skin conditions like Acne, Rosacea, or Eczema. Its lightweight, non-greasy texture provides easy application and rapid absorption, without leaving a white cast.
Dermdefence SPF 50 also serves as a primer, providing a smooth finish for easy makeup application and ensuring a flawless look all day. Dermdefence SPF 50 provides unparalleled sun protection that will shield your skin and nurture its unique needs, maintaining its health and radiance.
Coenzyme Q10
CoQ10 is a potent ingredient that offers comprehensive skin health and appearance benefits. Its role in energy production and its antioxidant and anti-aging properties make it invaluable for photoprotection, anti-aging, and overall skin vitality. Its incorporation into DermExcel sunscreen represents a holistic approach to skin health, addressing protective and restorative needs.
Physiological Impact
- Skin Barrier Enhancement: CoQ10 contributes to the strength and health of the skin barrier, improving its ability to retain moisture and protect against external irritants and pollutants.
- Skin Repair and Regeneration: It supports the skin's natural ability to repair itself and regenerate, maintaining a healthy, youthful appearance. This is particularly beneficial in mature skin, where natural levels of CoQ10 may be depleted.
Pharmacological Advantages
- Anti-Aging Effects: CoQ10's antioxidant properties contribute to its anti-aging effects. By reducing oxidative stress, it helps to minimize the visible signs of aging, such as wrinkles and fine lines.
- Photoprotection: It enhances the skin's defense against photoaging caused by exposure to UV rays. CoQ10 helps to mitigate the degradation of collagen and elastin, proteins essential for maintaining skin elasticity and firmness.
Biochemical Benefits
- Cellular Energy Production: CoQ10 plays a crucial role in the mitochondrial electron transport chain, which is essential for the production of ATP, the primary energy currency of the cell. This function is vital for maintaining the health and vitality of skin cells.
- Antioxidant Properties: It acts as a lipophilic antioxidant, neutralizing free radicals and preventing oxidative damage to cell membranes, proteins, and DNA. This is particularly important in the skin, which is frequently exposed to oxidative stress from environmental factors like UV radiation.
Infraguard™
Infraguard™ is a novel and powerful antioxidant powerhouse designed to protect the skin from the potentially harmful effects of electromagnetic radiation, specifically from 5G networks, blue light, and other environmental stressors. It shields the skin against oxidative stress and inflammation, prevents premature aging, and maintains overall health.
Infraguard® is a multifunctional ingredient that extends beyond traditional sun protection. It addresses the broader spectrum of light-induced skin damage and oxidative stress, provides DNA protection, and offers anti-aging benefits. Its inclusion in the DermExcel sunscreens represents an advanced step in comprehensive skin care, targeting UV rays and the often-overlooked infrared and blue light, ensuring a more holistic approach to maintaining skin health and appearance.
Physiological Effects
- Protection Against Blue Light and Infrared (IR) Radiation: Infraguard is formulated to shield the skin from the harmful effects of blue light and IR radiation, which can lead to premature skin aging and damage.
- Antioxidant Properties: It has strong antioxidant capabilities, helping to neutralize free radicals induced by environmental stressors such as pollution, IR, and blue light.
- Anti-Aging Benefits: By protecting against IR radiation and mitigating oxidative stress, Infraguard helps to prevent signs of aging like wrinkles and loss of skin elasticity.
- Skin Barrier Protection: Infraguard strengthens the skin's natural barrier, enhancing its resilience against environmental factors.
- DNA Protection: Infraguard™ aids in shielding the DNA in skin cells from damage caused by environmental aggressors. This is crucial in maintaining the integrity of skin cells and preventing mutations that can lead to skin aging and other skin-related issues.
Managing Dermatological Conditions
- Preventing Photoaging: Infraguard's ability to protect against IR and blue light makes it beneficial in preventing photoaging, a key concern in modern dermatology. Infrared light can penetrate deeper into the skin than UV rays, potentially leading to increased collagen degradation and skin laxity. Infraguard® helps mitigate these effects.
- Combatting Environmental Stressors: Its antioxidant properties protect the skin from various environmental pollutants and stressors.
- Supporting Skin Health: Infraguard contributes to overall skin health by improving the skin's barrier function and providing antioxidant support.
- Suitability for Diverse Skin Conditions: Given its protective and anti-aging properties, Infraguard is suitable for use in various dermatological conditions, especially environmental damage and aging.
References
- Kappler, Katharina et al. "Development of an in Vitro Assay to Evaluate the Biological Impact of 5G Technology on Human Skin. Journal of Cosmetics, Dermatological Sciences and Applications, 2022, vol. 12, pp. 100-108. DOI: 10.4236/jcdsa.2022.122009.
- Extensive references cited within the research article including studies on 5G technology, health effects, and skin biology.
Broad Spectrum Filters
Tinosorb® M and Tinosorb® S represent sophisticated advancements in sun protection technology.
Tinosorb® M
- Biochemical Action: A unique UV filter due to its ability to function through absorption, reflection, and scattering of UV rays.
- Physiological Impact: The triple-action mechanism of Tinosorb® M offers comprehensive sun protection. By mitigating the penetration of both UVA and UVB rays, it significantly reduces the risk of DNA damage, photoaging, and carcinogenesis. Its ability to remain on the skin's surface reduces systemic exposure, making it a safer option with minimal potential for irritation or allergic reactions.
Tinosorb® S
- Biochemical Action: A broad-spectrum UV filter with a molecular structure that effectively absorbs both UVA and UVB rays. Additionally, it enhances the photostability of other UV filters, making the sunscreen formulation more effective over time.
- Physiological Impact: By providing extensive UVA and UVB protection, Tinosorb® S plays a crucial role in preventing short-term sun damage like sunburn and long-term risks such as skin aging and skin cancer. Its photostability ensures sustained protection during sun exposure, and its compatibility with other UV filters means it can be used to formulate sunscreens that are both effective and suitable for sensitive skin.
Sunscreen
Using sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential for reducing the risk of skin cancers and photoaging and maintaining overall skin health in the face of constant exposure to UV radiation.
Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. Two primary types of UV radiation affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.
Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.
The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means it would take 30 times longer for your skin to burn than without sunscreen. However, it's important to note that no sunscreen can block 100% UV rays.
Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.
Managing Dermatological Conditions
- Prevention of Sunburn: Sunscreen protects the skin from UVB rays, which cause sunburn. This reduces the immediate risk of skin damage and discomfort.
- Skin Cancer Prevention: Regular use of sunscreen significantly lowers the risk of developing various types of skin cancer, especially melanoma, squamous cell carcinoma, and basal cell carcinoma.
- Prevention of Photoaging: Sunscreen also shields the skin from UVA rays, which penetrate deeper into the skin and are primarily responsible for photoaging, including wrinkles, leathery skin, and sunspots.
- Protection Against Photosensitivity: Sunscreen helps prevent flare-ups triggered by sun exposure for individuals with photosensitive skin conditions like lupus or rosacea.
- Hyperpigmentation and Melasma: It aids in preventing and managing hyperpigmentation and melasma, conditions exacerbated by sun exposure.
- General Skin Health: Sunscreen helps maintain overall skin health and integrity by protecting the skin from UV damage.
References
- Burnett, M. E., & Wang, S. Q. (2011). Current sunscreen controversies: a critical review. Photodermatology, Photoimmunology & Photomedicine.
- Green, A. C., et al. (2011). Reduced melanoma after regular sunscreen use: randomized trial follow-up. Journal of Clinical Oncology.
- Hughes, M. C. B., et al. (2013). Sunscreen and Prevention of Skin Aging: A Randomized Trial. Annals of Internal Medicine.
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