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DermExcel™ | Medi-Zinc Cleanser
DermExcel™ | Cleansers
Medi-Zinc Cleanser: Travel Size Medi-Zinc Cleanser: Travel Size Medi-Zinc Cleanser: Travel Size Medi-Zinc Cleanser: Travel Size
DermExcel™

Medi-Zinc Cleanser: Travel Size

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5.0 / 5.0 from 926 reviews

SIZE: 10 mL

Itch Relief

Itch Relief

Anti-Acne

Anti-Acne

↓ inflammation

↓ inflammation

anti-redness

anti-redness

Anti-microbial

Anti-microbial

A powerful hypoallergenic medicated solution with beneficial properties attributed to its active constituent, Zinc Pyrithione. This chemical compound, FDA-approved and clinically recognized, delivers strong antibacterial and antifungal action, making the cleanser an ideal choice for managing skin conditions associated with redness, flaking, irritation, and itching.

Zinc Pyrithione's efficacy, compounded by a gentle cleansing base, facilitates the lifting and removing of impurities, leaving the complexion refreshed. Concurrently, it sustains a tranquil skin environment, reducing inflammation and discomfort. As a daily cleansing aid, Medi-Zinc Cleanser proposes a reliable, scientifically-backed intervention in fostering skin health and comfort.

Zinc Pyrithione

Zinc Pyrithione

Zinc pyrithione, a compound with potent antifungal and antibacterial properties, has established itself as a cornerstone in the treatment of various skin conditions, particularly those involving Malassezia yeast. Its effectiveness against seborrheic dermatitis and dandruff, which are often associated with an overgrowth of Malassezia species, makes it a key ingredient for many dermatological conditions.

Zinc pyrithione’s mode of action is multifaceted, primarily targeting the membrane of fungi and bacteria, thereby disrupting their growth and replication. One of its significant mechanisms involves inhibiting fungal cell membrane transport by blocking the energy production pathway, which is crucial for cell survival.

In Malassezia, yeast, a natural inhabitant of the skin flora, can overgrow and cause conditions like seborrheic dermatitis and dandruff; zinc pyrithione's antifungal action is particularly beneficial. It reduces the yeast population on the skin, thereby alleviating the symptoms associated with its overgrowth, such as flaking, irritation, and redness.

Its efficacy in treating seborrheic dermatitis is attributed to its ability to reduce the Malassezia count, diminish inflammatory responses, and soothe the skin. Similarly, in dandruff, which is often linked to an excess of Malassezia, zinc pyrithione effectively reduces flaking and itchiness, promoting a healthier scalp environment.

The efficacy of zinc pyrithione in the treatment of seborrheic dermatitis and dandruff is well-documented. Its safety profile and efficacy have been confirmed by numerous studies, with significant improvements observed in both scalp and skin conditions following regular use.

Physiological Effects

  • Antifungal Activity: It is effective against a range of fungi, including those that cause dandruff and seborrheic dermatitis. Zinc Pyrithione inhibits the division of fungal cells, reducing their proliferation.
  • Antibacterial Properties: This compound also exhibits antibacterial activity, making it useful in treating and preventing bacterial skin infections.
  • Anti-inflammatory Effects: Zinc Pyrithione can reduce inflammation, which is beneficial in alleviating symptoms of various inflammatory skin conditions.
  • Sebum Regulation: It helps in regulating sebum production, which can be beneficial for oily skin and conditions like acne.

Managing Dermatological Conditions

  • Dandruff and Seborrheic Dermatitis: Zinc Pyrithione is a common ingredient in anti-dandruff shampoos and is effective in controlling the flaking and itching associated with these conditions.
  • Psoriasis: It can help manage the symptoms of psoriasis, particularly in reducing scaling and redness.
  • Acne: Due to its antibacterial and anti-inflammatory properties, Zinc Pyrithione can be beneficial in the treatment of acne.
  • Fungal Infections: It is effective in treating various fungal skin infections due to its antifungal properties.

References

  • Warshaw, E. M., et al. (2005). Efficacy of Zinc Pyrithione in Seborrheic Dermatitis and Dandruff. Dermatology.
  • Pierard-Franchimont, C., et al. (2002). Antidandruff shampoo efficacy in dandruff/seborrhoeic dermatitis. International Journal of Cosmetic Science.
  • Scheman, A., et al. (2000). Antimicrobial Activity of Zinc Pyrithione. American Journal of Infection Control.
Medi-Zinc Cleanser: Travel Size Medi-Zinc Cleanser: Travel Size Medi-Zinc Cleanser: Travel Size Medi-Zinc Cleanser: Travel Size

Medi-Zinc Cleanser: Travel Size

product benefits

Antibacterial and Anti-fungal Action

Antibacterial and Anti-fungal Action

Fights bacteria and fungi with 2% Zinc Pyrithione, reducing the risk of skin infections and helping to maintain a balanced and healthy skin microbiome.

Anti-inflammatory

Anti-inflammatory

Alleviates skin irritation and redness by targeting inflammatory pathways and markers, offering significant relief for inflamed skin conditions.

Reduce redness and irritation

Reduce redness and irritation

Control and reduce skin discomfort symptoms such as redness, flaking, irritation, and itching, improving overall skin comfort.

Sebum Regulation

Sebum Regulation

Implement effective sebum regulation strategies to minimize complications and refine the visual condition of oily skin.

Indications for Medi-Zinc Cleanser: Travel Size

Seborrheic Dermatitis
Facial and Body Acne
Rosacea / Red Skin
Inflammation
Clogged Pores
Folliculitis
Reduce redness
Sooth Irritated & Flaking Skin
Antibacterial and antifungal
Reduce inflammation
Healthy & comfortable skin

medi-zinc cleanser

mode of action

zinc pyrithione

effective treatment for skin conditions

atopic dermatitis and eczema
action
  • ZnPT formulated in body treatment is adjunctive to corticosteroid use for managing atopic dermatitis and eczema.
  • ZnPT alters skin levels of Malassezia yeast or Staphylococcus aureus bacteria, which is important in aggravating atopic dermatitis.
  • Malessezia yeast and its metabolites cause barrier aggravation in atopic dermatitis and eczema.
  • Approximately half of the differentially expressed stratum corneum proteins from dandruff and atopic dermatitis are the same, suggesting a common etiology.
evidence

A randomized controlled trial in children showed the benefits of ZnPT with lipids on skin microbiome diversity and atopic dermatitis score (SCORAD) when used in conjunction with 0.1% w/v hydrocortisone butyrate cream.

skin infection
action

ZnPT in antiseptic products has a significant clinical impact, such as reducing surgical site infections through extended anti-microbial persistence.

evidence
  • In an expanded flora test on the forearm, ZnPT exhibits gradual activity against a broad spectrum of gram-negative and gram-positive bacteria and RNA and DNA viruses for up to three days.
  • Concentrations up to 0.25% ZnPT with alcohol were superior to other combination agents (e.g., iodine, chlorhexidine gluconate, and triclosan) for the persistence of antimicrobial effects.
uvb induced hyperplasia
action

ZnPT treatment prevents UVB-induced photoaging and skin cancer development, potentially as an additive to sunscreens. Further work is needed to demonstrate human efficacy and establish therapeutic doses.

evidence

1% ZnPT scalp treatment prevented skin thickening in study subjects exposed to UVB radiation and normalized levels of hypoxia-inducible factor-1α, influencing the cell cycle.

atopic dermatitis and eczemaskin infectionuvb induced hyperplasia
action
  • ZnPT formulated in body treatment is adjunctive to corticosteroid use for managing atopic dermatitis and eczema.
  • ZnPT alters skin levels of Malassezia yeast or Staphylococcus aureus bacteria, which is important in aggravating atopic dermatitis.
  • Malessezia yeast and its metabolites cause barrier aggravation in atopic dermatitis and eczema.
  • Approximately half of the differentially expressed stratum corneum proteins from dandruff and atopic dermatitis are the same, suggesting a common etiology.

ZnPT in antiseptic products has a significant clinical impact, such as reducing surgical site infections through extended anti-microbial persistence.

ZnPT treatment prevents UVB-induced photoaging and skin cancer development, potentially as an additive to sunscreens. Further work is needed to demonstrate human efficacy and establish therapeutic doses.

evidence

A randomized controlled trial in children showed the benefits of ZnPT with lipids on skin microbiome diversity and atopic dermatitis score (SCORAD) when used in conjunction with 0.1% w/v hydrocortisone butyrate cream.

  • In an expanded flora test on the forearm, ZnPT exhibits gradual activity against a broad spectrum of gram-negative and gram-positive bacteria and RNA and DNA viruses for up to three days.
  • Concentrations up to 0.25% ZnPT with alcohol were superior to other combination agents (e.g., iodine, chlorhexidine gluconate, and triclosan) for the persistence of antimicrobial effects.

1% ZnPT scalp treatment prevented skin thickening in study subjects exposed to UVB radiation and normalized levels of hypoxia-inducible factor-1α, influencing the cell cycle.

Targets Malassezia Yeast: Zinc Pyrithione is particularly effective against Malassezia yeast, a fungus commonly found on the skin and scalp. This yeast can proliferate excessively, leading to dandruff and seborrheic dermatitis.

Disrupts Fungal Cell Membranes: Zinc Pyrithione works by disrupting the fungus's cell membranes, inhibiting its growth and survival. This action reduces the fungal population on the skin, alleviating symptoms associated with overgrowth.

Broad-Spectrum Activity: Zinc Pyrithione also possesses antibacterial properties that are effective against various bacteria that can contribute to skin irritation and infection. Reducing bacterial load helps prevent secondary infections and promotes skin healing.

Inhibits Bacterial Enzyme Systems: It interferes with enzyme systems within bacterial cells, leading to their death. This mechanism helps maintain skin flora balance and prevents conditions like acne and folliculitis.

mode of action

zinc pyrithione

rosacea & microbial skin conditions

antimicrobial

antimicrobial

Zinc Pyrithione inhibits microbial growth, particularly targeting Malassezia species associated with seborrheic dermatitis and fungal-related skin conditions, while reducing bacterial proliferation.

anti-inflammatory

anti-inflammatory

Helps reduce inflammation, redness, and irritation by calming inflammatory pathways within the skin, improving overall skin comfort in compromised conditions.

reduces scaling & flaking

reduces scaling & flaking

Zinc Pyrithione exhibits cytostatic activity, helping to normalise excessive keratinocyte proliferation. This reduces scaling, flaking, and buildup on the skin.

Testimonials

Customer Reviews

Based on 926 reviews
96%
(891)
3%
(31)
0%
(4)
0%
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C
CORNE EAGLETON
Renewal facial cleanser

Love the product.

C
Colette Sandenbergh
Pores Gone

I can not believe what this product is doing to my skin. Amazing

X
Xante Greyvenstein
Love the Medi Zinc Cleanser

It has cleared my skin up so nicely a d settled my redness. Would 10/10 recommend it to anyone struggling with acne prone sensitive skin. Love it!

M
Monique Theron

Pore Control Cleanser

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