Neo Heliopan® 357, commonly known as Avobenzone offers significant benefits from biochemical, pharmacological, and physiological perspectives:

Biochemical Benefits

• UVA Absorption: It functions by absorbing UVA radiation, particularly in the 320-400 nm range, which includes both UVA1 and UVA2 rays. Biochemically, it absorbs high-energy UVA photons and releases the energy as lower-energy photons, thereby preventing the UV radiation from penetrating deeper into the skin and causing cellular damage.
• Prevention of Photoaging: By absorbing UVA rays, it helps prevent the biochemical processes that lead to photoaging, such as degradation of collagen and elastin, which are vital for maintaining skin structure and elasticity.

Pharmacological Advantages

• Protection Against Long-Term Skin Damage: Help to protect the skin from long-term damage such as photoaging, hyperpigmentation, and the development of certain types of skin cancer associated with UVA exposure.
• Synergistic Effect: Often used in combination with other UVB and UVA filters, it contributes to a broad-spectrum protection profile, enhancing the overall efficacy of sunscreen.

Physiological Impact

• Skin Aging Prevention: Protects the skin from UVA radiation and minimizing the signs of aging caused by UVA-induced damage.
• Enhanced Skin Health: By filtering out harmful UVA rays, it aids in maintaining overall skin health, preventing the breakdown of DNA in skin cells, and reducing oxidative stress.

Uvinul® T 150 and Uvinul® MC 80 offer superior UVB protection, high photostability and very good skin compatibility.

Uvinul® T 150

• High UVB Absorption: Uvinul® T 150 is known for its exceptionally high UVB absorption. It is one of the most efficient UVB filters on a per weight basis, meaning less of it is required to achieve the same level of protection as other filters.
• Photostability: This compound is highly photostable, meaning it doesn't degrade easily when exposed to sunlight. This property is crucial for maintaining consistent UV protection over time.
• Water Resistance: Uvinul® T 150 improve the water resistance of our sunscreen, beneficial for when you have swimming or outdoor activities.
• Low Irritation Potential: It is generally well-tolerated by the skin, with a lower risk of irritation or sensitization compared to other UVB filters.

Uvinul® MC 80

• Efficacy: With an extensive and impressive safety and efficacy history, Uvinul® MC 80 is highly effective in protecting the skin from UVB rays, which are primarily responsible for sunburn and can contribute to skin cancer.
• Elegance: Uvinul® MC 80 have a fantastic texture, leaving no white cast.

Using sunscreen is a fundamental aspect of skin care and preventive dermatology. It's essential for reducing the risk of skin cancers and photoaging and maintaining overall skin health in the face of constant exposure to UV radiation.

Sunscreen is a vital skincare product designed to protect the skin from the harmful effects of ultraviolet (UV) radiation from the sun. Two primary types of UV radiation affect the skin: UVA and UVB. UVA rays penetrate deep into the skin and are primarily responsible for aging and long-term skin damage, whereas UVB rays cause sunburn and play a key role in developing skin cancer.

Sunscreen products work by either absorbing, reflecting, or scattering sunlight. They contain chemical compounds that absorb UV radiation and convert it into a small amount of heat or physical compounds (like zinc oxide or titanium dioxide) that act as a physical barrier, reflecting UV light away from the skin.

The effectiveness of sunscreen is measured by its Sun Protection Factor (SPF). SPF indicates how well the sunscreen protects against UVB rays. For example, an SPF of 30 means it would take 30 times longer for your skin to burn than without sunscreen. However, it's important to note that no sunscreen can block 100% UV rays.

Regular use of sunscreen with an SPF of at least 30 can reduce the risk of skin cancer, prevent sunburn, and slow down the skin's aging process.

Tinosorb® M and Tinosorb® S represent sophisticated advancements in sun protection technology.

CoQ10 is a potent ingredient that offers comprehensive skin health and appearance benefits. Its role in energy production and its antioxidant and anti-aging properties make it invaluable for photoprotection, anti-aging, and overall skin vitality. Its incorporation into DermExcel sunscreen represents a holistic approach to skin health, addressing protective and restorative needs.

Infraguard™ is a novel and powerful antioxidant powerhouse, designed to protect the skin from the potentially harmful effects of electromagnetic radiation, specifically from 5G networks, blue light, and other environmental stressors. It functions by shielding the skin against oxidative stress and inflammation, contributing to the prevention of premature aging and maintaining overall skin health.

Physiological Effects of Infraguard

1. Protection Against Blue Light and Infrared (IR) Radiation: Infraguard is formulated to shield the skin from the harmful effects of blue light and IR radiation, which can lead to premature skin aging and damage.
2. Antioxidant Properties: It has strong antioxidant capabilities, helping to neutralize free radicals induced by environmental stressors such as pollution, IR, and blue light.
3. Anti-Aging Benefits: By protecting against IR radiation and mitigating oxidative stress, Infraguard helps to prevent signs of aging like wrinkles and loss of skin elasticity.
4. Skin Barrier Protection: Infraguard aids in reinforcing the skin's natural barrier, enhancing its resilience against environmental factors.
5. DNA Protection: Infraguard™ aids in shielding the DNA in skin cells from damage caused by environmental aggressors. This is crucial in maintaining the integrity of skin cells and preventing mutations that can lead to skin aging and other skin-related issues.

Role and Benefits in Dermatology

1. Preventing Photoaging: Infraguard's ability to protect against IR and blue light makes it beneficial in preventing photoaging, a key concern in modern dermatology. Infrared light can penetrate deeper into the skin compared to UV rays, potentially leading to increased collagen degradation and skin laxity. Infraguard® helps in mitigating these effects.
2. Combatting Environmental Stressors: Its antioxidant properties make it effective in protecting the skin from various environmental pollutants and stressors.
3. Supporting Skin Health: By improving the skin's barrier function and providing antioxidant support, Infraguard contributes to overall skin health.
4. Suitability for Diverse Skin Conditions: Given its protective and anti-aging properties, Infraguard is suitable for use in a wide range of dermatological conditions, especially those related to environmental damage and aging.

References

• Kappler, Katharina et al. "Development of an in Vitro Assay to Evaluate the Biological Impact of 5G Technology on Human Skin. Journal of Cosmetics, Dermatological Sciences and Applications, 2022, vol. 12, pp. 100-108. DOI: 10.4236/jcdsa.2022.122009​​.
• Extensive references cited within the research article including studies on 5G technology, health effects, and skin biology​​.

Infraguard® is a multifunctional ingredient that extends beyond traditional sun protection. It addresses the broader spectrum of light-induced skin damage and oxidative stress, provides DNA protection, and offers anti-aging benefits. Its inclusion in the DermExcel sunscreens represents an advanced step in comprehensive skin care, targeting not just UV rays but also the often-overlooked infrared and blue light, thereby ensuring a more holistic approach to maintaining skin health and appearance.

The benefits of the fat-soluble Vitamin E in maintaining skin health and appearance are well-acknowledged in both cosmetic and clinical dermatology. Comprising a group of eight compounds, including four tocopherols and four tocotrienols, Vitamin E is known for its role in protecting cell membranes from oxidative damage.

In skincare, Vitamin E is celebrated for its ability to neutralize free radicals caused by environmental stressors such as UV radiation and pollution. These free radicals can lead to premature skin aging, making Vitamin E a valuable ingredient in anti-aging skincare products. Its antioxidant action helps to protect the skin from damage, reduce the appearance of wrinkles, and improve skin texture and tone.

Additionally, Vitamin E is known for its moisturizing benefits. It helps to strengthen the skin barrier, reducing moisture loss and keeping the skin hydrated and supple. This makes it especially beneficial for dry and damaged skin.

Vitamin E also has anti-inflammatory properties, making it beneficial in soothing and calming irritated skin. This has implications for conditions such as dermatitis and acne, where inflammation plays a key role.

Physiological Effects of Vitamin E

1. Antioxidant Protection: Vitamin E neutralizes harmful free radicals in the skin, preventing oxidative stress and damage caused by environmental factors like UV radiation and pollution.
2. Moisturization: It has moisturizing properties, helping to improve skin hydration and alleviate dryness.
3. Wound Healing: Vitamin E may assist in the skin's healing process, although its efficacy in wound healing is still a subject of research.
4. Photoprotection: While not a sunscreen, it can provide some degree of photoprotection by strengthening the skin's defense against UV-induced damage.
5. Anti-Inflammatory Effects: It helps reduce skin inflammation, beneficial in managing conditions like eczema and psoriasis.

Role in Managing Dermatological Conditions

1. Skin Aging: Its antioxidant properties make it useful in anti-aging skincare products to protect against free radical damage and improve skin appearance.
2. Dry Skin Conditions: Vitamin E's moisturizing effects are beneficial in treating dry skin and improving overall skin texture.
3. Inflammatory Skin Diseases: It can be helpful in soothing inflammatory skin conditions like eczema and psoriasis.
4. Sun Protection and Repair: Vitamin E is included in sunscreens and after-sun products for its ability to mitigate sun damage.
5. Scar Treatment: Some studies suggest Vitamin E may help in reducing the appearance of scars, although evidence is mixed.

References

• Thiele, J. J., Hsieh, S. N., & Ekanayake-Mudiyanselage, S. (1998). Vitamin E: Critical Review of Its Current Use in Cosmetic and Clinical Dermatology. Dermatologic Surgery, 24(7), 805–813.
• Ratz-Łyko, A., & Arct, J. (2016). Anti-inflammatory and anti-aging properties of active skin care ingredients. Journal of Clinical and Aesthetic Dermatology, 9(9), 36–40.
• Keen, M. A., & Hassan, I. (2016). Vitamin E in dermatology. Indian Dermatology Online Journal.
• Ekanayake-Mudiyanselage, S., & Thiele, J. (2007). Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.
• Nachbar, F., & Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.

Glycerin, also known as glycerol, is a simple polyol compound widely used in dermatology due to its excellent moisturizing properties.

Glycerin's excellent hydrating properties, combined with its ability to soothe and improve skin barrier function, make it a highly valued ingredient in the treatment and management of various dermatological conditions, particularly those involving dryness and compromised skin barrier.

Physiological effects of Glycerin

1. Hydration: Glycerin is a humectant, meaning it attracts water to the skin. It draws moisture from the environment and the deeper layers of the skin to the outer layer (stratum corneum), improving hydration.
2. Skin Barrier Function: By enhancing skin hydration, glycerin helps to maintain and improve the skin's barrier function, protecting against irritants and reducing transepidermal water loss (TEWL).
3. Soothing Effect: It has a soothing effect on the skin, which can be beneficial in reducing irritation and discomfort in various skin conditions.
4. Elasticity and Resilience: Glycerin can improve skin elasticity and resilience, making the skin appear healthier and more supple.
5. Wound Healing: Some studies suggest glycerin may play a role in accelerating wound healing processes and improving skin repair.

Role in Managing Dermatological Conditions

1. Dry Skin Conditions (Xerosis): Glycerin is a key ingredient in many moisturizers and is highly effective in managing dry skin by providing deep hydration.
2. Eczema and Dermatitis: Its moisturizing and soothing properties help in relieving the symptoms of eczema and dermatitis, such as dryness, itching, and irritation.
3. Psoriasis: Glycerin can aid in reducing the dryness and scaling associated with psoriasis.
4. Aging Skin: It is beneficial in anti-aging products due to its ability to hydrate the skin and improve its elasticity.
5. Wound Care: Glycerin-based products may be used in the care of minor wounds and burns due to its potential role in enhancing wound healing.

References

• Fluhr, J. W., Darlenski, R., & Surber, C. (2008). Glycerol and the skin: holistic approach to its origin and functions. British Journal of Dermatology.
• Harding, C. R. (2004). The stratum corneum: structure and function in health and disease. Dermatologic Therapy.
• Lodén, M. (2005). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology.

Humectants are a vital component in skincare, particularly for conditions characterized by impaired skin barrier function and excessive dryness. Their ability to attract and retain moisture in the skin makes them invaluable in both therapeutic and preventive dermatology.

Emollients are crucial in dermatological care, primarily because they enhance skin hydration and barrier function. Here's a brief overview of their physiological effects and roles in managing various skin conditions.