Curexema: Trial
SIZE: 10 mL
Ichthyosis
Eczema
Inflammation
Rough texture
Dry skin
Intense multi-lamellar moisturizing complex for very dry skin conditions, including eczema, dermatitis, psoriasis, and ichthyosis.
Unlock your skin's potential with Curexema, a body moisturizer specially formulated for those struggling with eczema, dry and dehydrated skin, psoriasis, and rough, scaling skin. Powered by advanced Dual Lipid Bilayer Technology, Curexema creates a double structural layer on the skin's surface, expertly regulating water loss and reinforcing the skin's natural barrier.
Immerse your skin in the optimal blend of Niacinamide, Hyaluronic Acid, d-Panthenol, and Glycerin, designed to protect the skin's barrier function, enhance texture and resilience, and reduce inflammation. With Niacinamide providing essential energy for skin cell repair, Curexema works to transform your skin from within.
Nourish your skin with the healing power of Ceramides, essential fatty acids, and Cholesterol. This potent combination rebuilds the skin's epidermal barrier, restoring structural integrity and enveloping the skin barrier in vital moisture and nourishment. Experience strengthened, soothed, and supple skin with Curexema.
Replenish your skin's essential lipids for optimal dry skin recovery, as Curexema delivers instant relief from itching, dryness, redness, roughness, and scaling.
Lipid bilayer technology in dermatology focuses on mimicking and reinforcing the skin's natural lipid barrier, which is vital for maintaining skin health and integrity.
Physiological Effects
- Reinforcement of Skin Barrier: Lipid bilayer technology aims to replicate the skin's natural barrier, particularly beneficial for damaged or compromised skin. This reinforcement helps in reducing transepidermal water loss (TEWL) and enhancing skin hydration.
- Restoration of Lipid Composition: It helps in replenishing the essential lipids that are often deficient in certain skin conditions, thereby restoring the skin's natural protective barrier.
- Improvement in Skin Texture and Hydration: By restoring the lipid bilayer, this technology improves skin texture and overall hydration, leading to healthier, more resilient skin.
- Reduction of Inflammation and Irritation: It can help in reducing inflammation and irritation, particularly in conditions where the skin barrier is compromised.
Role in Managing Dermatological Conditions
- Atopic Dermatitis (Eczema): Lipid bilayer technology is particularly beneficial in managing eczema, as it helps in restoring the deficient skin barrier function, reducing dryness, and controlling flare-ups.
- Psoriasis: In psoriasis, where the skin barrier is also disrupted, this technology aids in hydrating the skin and reducing scaling.
- Aging Skin: The aging skin, which naturally loses lipids over time, benefits from lipid bilayer technology as it helps in maintaining skin hydration and elasticity.
- Dry Skin Conditions (Xerosis, Ichthyosis): Enhancing the skin’s lipid content can significantly improve symptoms of dryness and scaling in these conditions.
- Sensitive Skin: For sensitive skin types, lipid bilayer technology can provide a gentle and effective way to strengthen the skin barrier without causing irritation.
References
- Del Rosso, J. Q., & Levin, J. (2011). The Clinical Relevance of Maintaining the Functional Integrity of the Stratum Corneum in both Healthy and Disease-affected Skin. Journal of Clinical and Aesthetic Dermatology.
- Rawlings, A. V., & Harding, C. R. (2004). Moisturization and Skin Barrier Function. Dermatologic Therapy.
- Man, M. Q., Xin, S. J., Song, S. P., Cho, S. Y., Zhang, X. J., Tu, C. X., ... & Elias, P. M. (2009). Variation of Skin Surface pH, Sebum Content and Stratum Corneum Hydration with Age and Gender in a Large Chinese Population. Skin Pharmacology and Physiology.
Niacinamide offers several benefits for the skin, primarily due to its anti-inflammatory and antioxidant properties. It reduces the redness and inflammation associated with acne, rosacea, and other inflammatory skin conditions. Additionally, niacinamide's ability to improve the skin's barrier function benefits all skin types, particularly those with eczema or mature skin.
Another significant benefit of niacinamide is its role in reducing hyperpigmentation. Studies have shown that it can decrease the transfer of melanin to the epidermis, helping to fade dark spots and even out skin tone.
Niacinamide also plays a role in reducing the visible signs of aging. It has been found to stimulate collagen production and improve skin elasticity, reducing fine lines and wrinkles. Its antioxidant properties further protect the skin from environmental damage, such as pollution and UV radiation, which contribute to premature aging.
The efficacy of niacinamide and its ability to address multiple skin concerns simultaneously has led to its growing popularity in both over-the-counter and prescription skincare formulations.
Physiological Effects
- Barrier Function Enhancement: Niacinamide helps strengthen the skin’s barrier function by increasing the production of ceramides, lipids that keep the skin hydrated and protect against environmental damage.
- Anti-inflammatory Properties: It has notable anti-inflammatory effects, which are beneficial in reducing redness and inflammation associated with acne, eczema, and other inflammatory skin conditions.
- Sebum Regulation: Niacinamide helps regulate sebum production, which controls excess oiliness and can benefit acne-prone skin.
- Hyperpigmentation Reduction: It reduces hyperpigmentation by inhibiting melanosome transfer from melanocytes to keratinocytes, leading to an even skin tone.
- Anti-aging Effects: Niacinamide helps reduce the appearance of fine lines and wrinkles by boosting collagen production and improving skin elasticity.
- Antioxidant Activity: It has antioxidant properties, protecting the skin from oxidative stress and environmental aggressors like UV radiation and pollution.
Role in Managing Dermatological Conditions
- Acne and Oily Skin: Niacinamide effectively manages acne and oily skin by regulating sebum and reducing inflammation.
- Hyperpigmentation and Melasma: Its ability to reduce melanin transfer benefits it in treating hyperpigmentation and melasma.
- Aging Skin: Niacinamide targets wrinkles and loss of firmness.
- Skin Barrier Disorders: Niacinamide is beneficial in treating skin barrier disorders like atopic dermatitis and eczema by enhancing barrier function and hydration.
- Photodamage and Skin Protection: It helps mitigate the effects of photodamage and provides some degree of protection against environmental damage.
References
- Gehring, W. (2004). Nicotinic acid/niacinamide and the skin. Journal of Cosmetic Dermatology.
- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery.
- Snaidr, V. A., Damian, D. L., & Halliday, G. M. (2019). Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Experimental Dermatology.
- Navarrete-Solís, J. et al. (2011). A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma. Dermatology Research and Practice, 2011.
Ceramides, a family of lipid molecules naturally present in the skin, are integral to the structure and function of the skin barrier. They are a type of lipid that, along with cholesterol and fatty acids, forms a critical part of the stratum corneum, the outermost layer of the skin. This layer is essential for maintaining skin hydration and protecting against environmental aggressors.
Ceramides, which make up about 50% of the skin's lipid composition, play a pivotal role in maintaining the skin's barrier integrity and preventing transepidermal water loss (TEWL). By doing so, they help keep the skin hydrated and supple.
The loss or reduction of ceramides in the skin barrier is associated with several dermatological conditions, including eczema and psoriasis, where the skin becomes dry, itchy, and prone to irritation and infection. Studies have shown that the application of ceramide-containing moisturizers can effectively improve skin barrier function and increase skin hydration levels.
Ceramides are particularly beneficial for aging skin, which naturally loses ceramides over time, leading to drier and more fragile skin. By replenishing the skin's ceramide content, these products can help combat the signs of aging, such as fine lines and wrinkles.
Ceramides are integral to maintaining skin health, particularly in conditions where the skin barrier is compromised. Their role in hydrating the skin, reducing sensitivity, and improving barrier function makes them an essential component in the management of various dermatological conditions, especially eczema, psoriasis, and dry or aging skin.
Physiological Effects
- Barrier Function: Ceramides are critical components of the skin's lipid barrier. They help to prevent moisture loss and protect against environmental aggressors like pollutants and irritants.
- Hydration: By maintaining the barrier integrity, ceramides keep the skin hydrated, preventing dryness and keeping the skin supple.
- Reducing Skin Sensitivity: They play a role in reducing skin sensitivity and irritation, helping to calm inflamed and reactive skin.
- Anti-aging Properties: Ceramides can improve skin elasticity and firmness, helping to reduce the appearance of fine lines and wrinkles.
- Wound Healing: There is evidence to suggest that ceramides can aid in the skin's natural wound healing process.
Role in Managing Dermatological Conditions
- Eczema and Atopic Dermatitis: Ceramides are often used in the treatment of eczema and atopic dermatitis, where the skin barrier is compromised, leading to dryness, itching, and inflammation.
- Psoriasis: They can help in managing psoriasis by maintaining skin hydration and barrier function, reducing scaling and dryness.
- Aging Skin: Ceramide-containing products are beneficial in anti-aging regimens due to their ability to improve skin barrier function and elasticity.
- Dry Skin (Xerosis): In the treatment of dry skin, ceramides help in restoring skin hydration and barrier function.
- Sensitive Skin: Products containing ceramides are suitable for sensitive skin as they help to restore the skin's natural barrier and reduce irritation.
References
- Del Rosso, J. Q., & Levin, J. (2011). The clinical relevance of maintaining the functional integrity of the stratum corneum in both healthy and disease-affected skin. Journal of Clinical and Aesthetic Dermatology.
- Farwanah, H., Wohlrab, J., Neubert, R. H. H., & Raith, K. (2005). Ceramides and skin function. American Journal of Clinical Dermatology.
- Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Dermato-Venereologica.
d-Panthenol's multifaceted effects on skin hydration, barrier strengthening, and wound healing make it a valuable component in the management of various dermatological conditions, from dry skin to post-procedure care.
d-Panthenol, also known as pro-vitamin B5, is a popular dermatological ingredient due to its beneficial effects on the skin. Here's a brief overview of its physiological effects and roles in managing various skin conditions:
Physiological Effects
- Hydration: d-Panthenol is a humectant, meaning it helps to attract and retain moisture in the skin. This leads to increased skin hydration, which can improve skin softness and elasticity.
- Wound Healing and Repair: It plays a role in the synthesis of lipids and proteins, essential for skin repair. d-Panthenol has been shown to accelerate re-epithelialization in wound healing.
- Anti-Inflammatory Effect: d-Panthenol can reduce inflammation, making it beneficial in treating skin irritations and erythema.
- Skin Barrier Strengthening: By enhancing the synthesis of lipids and proteins, d-Panthenol contributes to the strengthening of the skin's barrier function, protecting against irritants and environmental damage.
- Soothing and Softening: It soothes the skin and makes it feel softer and smoother, which can be particularly beneficial for dry or rough skin textures.
Role in Managing Dermatological Conditions
- Minor Wounds and Skin Irritations: Due to its role in skin repair and anti-inflammatory properties, d-Panthenol is used in the treatment of minor wounds, cuts, and skin irritations.
- Dermatitis and Eczema: It helps in managing conditions like dermatitis and eczema by reducing inflammation and enhancing skin barrier function.
- Dry Skin Conditions (Xerosis): Its moisturizing properties make it effective in treating dry skin, providing relief from itching and scaling.
- Post-procedure Care: d-Panthenol is often used in post-procedure care, such as after laser treatments or chemical peels, to aid in skin recovery and reduce inflammation.
References
- Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. Journal of Dermatological Treatment.
- Ebner, F., Heller, A., Rippke, F., & Tausch, I. (2002). Topical use of dexpanthenol in skin disorders. American Journal of Clinical Dermatology.
- Camargo, F. B. Jr, Gaspar, L. R., & Maia Campos, P. M. B. G. (2011). Skin moisturizing effects of panthenol-based formulations. Journal of Cosmetic Science.
Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.
Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.
Physiological Effects
- Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
- Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
- Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
- Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
- Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
- Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
- Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
- Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.
Role in Managing Dermatological Conditions
- Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
- Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
- Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
- Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
- Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.
References
- Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
- Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
- DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
- Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
- ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.
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Choose options
- Dry Skin (Xerosis): Provides hydration and nourishment, making the skin soft and supple.
- Atopic dermatitis / Eczema: Reinforce the skin's natural barrier and address the symptoms of eczema, including dryness, itching, and inflammation.
- Ichthyosis: Effective in addressing the scaling, roughness, and excessive dryness associated with ichthyosis, a genetic disorder that impairs the skin's ability to retain moisture.
- Compromised skin barrier: Intelligent Lipid Bilayer technology helps to regulate water loss, strengthen and regenerate the skin's natural barrier and reduce inflammation.
- Rough and scaling skin: Alleviate rough and scaling skin symptoms, making it smoother and healthier.
- Rough or uneven skin texture: Improve skin texture by providing nutrients and hydration.
- Sensitive skin: Gentle on sensitive skin types, reducing irritation and discomfort.
- Psoriasis: Relieve symptoms of psoriasis, such as dryness, itching, and inflammation.
- Aging skin: Address aging skin by supporting the skin barrier, retaining moisture, and improving skin elasticity.
Active ingredients
- Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
- Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
- Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
- Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
- Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
- Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
- Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
- Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.
- Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
- Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
- Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
- Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
- Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.
- Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
- Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
- DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
- Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
- ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.
- Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
- Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
- Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
- Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
- Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
- Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
- Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
- Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.
- Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
- Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
- Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
- Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
- Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.
- Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
- Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
- DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
- Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
- ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.
- Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
- Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
- Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
- Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
- Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
- Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
- Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
- Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.
- Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
- Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
- Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
- Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
- Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.
- Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
- Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
- DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
- Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
- ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.
- Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
- Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
- Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
- Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
- Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
- Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
- Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
- Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.
- Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
- Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
- Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
- Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
- Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.
- Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
- Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
- DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
- Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
- ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.
- Emollient: Medilan™ is an excellent emollient, helping to soften and smooth the skin by retaining moisture. It creates an occlusive barrier, which reduces transepidermal water loss (TEWL).
- Moisturizing: It is highly effective in moisturizing dry and rough skin, enhancing skin hydration by trapping and sealing in moisture.
- Hypoallergenic: Medilan™ is ultra-purified to minimize the risk of allergic reactions, making it suitable for sensitive skin types.
- Wound Healing: Medilan™ aids in the healing process of minor cuts, abrasions, and burns by maintaining a moist wound environment.
- Skin Barrier Function: It enhances the skin's barrier function, protecting against environmental irritants and reducing the risk of skin infections.
- Lipid Replenishment: Medilan™ mimics the lipids found in human skin, helping to restore the lipid barrier of the skin, especially beneficial in dry and chapped skin conditions.
- Skin Penetration and Hydration: It can penetrate the skin and aid in water retention in the stratum corneum, the outermost layer of the skin, thus enhancing hydration.
- Occlusive Properties: Medilan™ helps reduce transepidermal water loss by forming a barrier on the skin surface, thereby retaining moisture and improving skin barrier function.
- Eczema and Dry Skin Conditions: Medilan™ is a valuable ingredient in treating eczema and other dry skin conditions due to its soothing, hydrating, and occlusive properties.
- Wound Healing: While primarily used for its emollient effects, the properties of Medilan™ also aid in healing minor wounds and skin irritations.
- Sensitive Skin Care: Its hypoallergenic nature makes it suitable for sensitive skin, reducing the risk of irritation or allergic reactions.
- Nipple Care in Breastfeeding: Soothes and heals cracked and sore nipples in breastfeeding mothers.
- Chapped Lips and Skin: It effectively treats chapped lips and skin, providing a barrier that seals in moisture and protects from harsh weather conditions.
- Lodén, M., & Maibach, H. I. (2000). Dry skin and moisturizers: chemistry and function. CRC Press.
- Suleman, H., et al. (2000). Role of lanolin in managing eczema and dry skin conditions. Community Nurse.
- DiNardo, J. C. (2000). Is lanolin allergy a myth? Dermatitis.
- Stone, L. (2000). Medilan: a hypoallergenic lanolin for emollient therapy. British Journal of Nursing.
- ResearchGate Article on Medilan™ highlighting its role in skin care and emollient therapy.
Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.
Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.
Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.
Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.
Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.
Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.
Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.
Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.
Medilan™'s unique formulation and hypoallergenic properties make it a valuable component in managing various dermatological conditions, particularly for hydrating and soothing sensitive and dry skin.
Medilan™, an ultra-refined, hypoallergenic medical-grade lanolin, has proven to be very beneficial for managing dermatological conditions. Below is a brief overview of its physiological effects and roles in managing various skin conditions.
Full ingredient list
Aqua, white soft paraffin, extra pure lanolin, emulsifying wax, glycerin, stearic acid, ceramides, cholesterol, liquid paraffin, niacinamide, cetyl alcohol, cetomacrogol, isostearyl isostearate, potassium cetyl phosphate, cetyl stearate, stearic acid, ethyl hexyl glycerin, phenoxyethanol, carbomer, d-panthenol, sodium hyaluronate, C12-17 alkane, triethanolamine.
Morning & / or Evening
- Application time: Morning and/or Evening.
- Frequency: Daily.
1. Cleanse
Gently cleanse your skin with a mild, non-irritating body wash or cleanser. We recommend Dermaplan's Cremedify.
2. Pat your skin
Use a clean, soft towel to pat your skin. Leave your skin slightly damp. This will help your skin better absorb the moisturizer and maximize its benefits.
3. Apply
Massage Curexema cream into your skin using circular motions, focusing on areas of concern.
Usage frequency
- For optimal results, apply Curexema twice daily or as directed by your healthcare professional. This will ensure consistent skin hydration and support the repair of your skin's natural barrier.
- During eczema flare-ups, you may increase the frequency of application as needed to provide additional relief and support skin recovery. Consult your healthcare professional for personalized recommendations based on your specific skin condition.
curexema
mode of action
Ceramides
Ceramides play a crucial role in maintaining the skin's barrier function and overall health at the physiological level. Their mode of action involves several vital mechanisms:
- Structural Role in Skin Barrier: The skin barrier, primarily located in the stratum corneum (the outermost layer of the skin), consists of corneocytes (dead skin cells) embedded in a lipid matrix. This matrix comprises ceramides, cholesterol, and free fatty acids in a specific ratio. Ceramides are the largest component and are essential for the barrier's structural integrity, functioning like the 'mortar' that holds the 'bricks' (corneocytes) together. By maintaining this structure, ceramides prevent excessive water loss and protect against the entry of harmful substances.
- Hydration and Water Retention: Ceramides help the skin retain moisture by forming a protective layer that limits water evaporation. This is crucial for keeping the skin hydrated, plump, and resilient.
- Regeneration and Repair: Ceramides can support the skin's natural repair processes, particularly after damage caused by environmental factors like UV radiation, pollution, and irritants. They help restore the barrier function, promoting healing and reducing the risk of skin conditions such as dermatitis and eczema.
- Anti-inflammatory Properties: Some studies suggest that ceramides may possess anti-inflammatory properties. These properties help soothe irritated skin and reduce inflammation, beneficial in conditions like psoriasis and eczema.
- Signaling Molecules: Beyond their structural role, ceramides also function as signaling molecules that can influence cell proliferation, differentiation, and apoptosis (programmed cell death). This is significant for skin homeostasis and maintaining a healthy skin barrier.
References:
- Pilgram, G.S.K., Vissers, D.C.J., van der Meulen, H., Pavel, S., Lavrijsen, S.P.M., Bouwstra, J.A., Koerten, H.K. (2001). The effect of 2-hydroxyoctadecanoic acid on human skin and its role in dry skin conditions. Archives of Dermatological Research, 293(4), 191-197.
- Elias, P.M., Wakefield, J.S. (2014). Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis. Clinical Reviews in Allergy & Immunology, 41(3), 282-295.
- Uchida, Y. (2014). Ceramide signaling in mammalian epidermis. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1841(3), 453-462.
These references highlight the critical role of ceramides in skin physiology, underpinning their use in dermatological products like Curexema for treating and managing dry skin conditions.
Lipid-Bilayer Technology
DuraQuench IQ SA functions by forming an intelligent lipid bilayer on the skin's surface to regulate water loss and interacting with the lipid bilayers within the stratum corneum to reinforce the skin's natural barrier.
This dual-action mechanism helps retain moisture and enhance the skin's protective barrier, leading to prolonged skin hydration, reduced water loss under varying environmental conditions, and improved skin condition even after wash-off applications.
The intelligent lipid bilayer formed by DuraQuench IQ SA is achieved through a combination of specific ingredients that work synergistically.
Potassium Cetyl Phosphate: Contributes to the formation of lipid bilayers on the skin's surface.
Isostearyl Isostearate: Reinforces the skin's natural barrier.
Stearic Acid and Cetyl Stearate: Replenish long-chain fatty acids and esters typically depleted in dry skin.
Cetyl Alcohol: Assists in forming liquid crystals, enhancing the moisturizing effect and the stability of the lipid bilayer structure.
Emmolients
Main Benefits of Emollients
- Hydration: Emollients fill in the gaps between skin cells that are missing moisture, effectively hydrating the skin. Replenishing lost water content helps to maintain the skin's natural moisture balance, making the skin feel softer and smoother.
- Barrier Protection: They form a protective layer over the skin surface, which helps to prevent transepidermal water loss (TEWL), a common issue in dry and eczema-prone skin. This protective layer shields the skin from environmental irritants and allergens, reducing the risk of flare-ups and infections.
- Skin Repair: Emollients help to repair the skin barrier function, which is often compromised in conditions like eczema, psoriasis, and dermatitis. By restoring the integrity of the skin barrier, emollients can improve the skin's resilience against irritants and reduce symptoms of itchiness and inflammation.
- Flexibility and Elasticity: By keeping the skin moist, emollients increase its flexibility and elasticity, which can help to prevent cracks and fissures in dry or thickened skin areas. This is particularly beneficial in preventing the skin from becoming brittle and breaking, especially in areas prone to eczema or psoriasis.
- Soothing Effect: Emollients have a soothing effect on the skin, relieving itching and discomfort associated with dryness and skin conditions. This can help to reduce scratching, which in turn prevents further skin damage and potential infections.
- Enhanced Skin Appearance: Regular use of emollients can improve the appearance of the skin, making it look healthier and more vibrant. They can help to diminish the appearance of dry or flaky skin, providing a smoother and more even skin texture.
Emollients are beneficial for maintaining and restoring skin health, offering hydration, protection, and relief from various skin conditions. Their regular application is key in managing dry skin, enhancing skin barrier function, and improving overall skin appearance and comfort.
Occlusives
Occlusives form a protective layer on the skin's surface. This layer is a barrier, preventing water loss and shielding the skin from external irritants.
Main benefits of Occlusives
- Prevention of Transepidermal Water Loss (TEWL): Occlusives create a physical barrier on the skin that prevents moisture from evaporating into the air. This is especially beneficial in dry environments where the skin is prone to losing moisture quickly.
- Enhanced Skin Hydration: Occluives help prevent water loss and maintain and enhance the skin's hydration levels. This can lead to improved skin texture, making it feel smoother and softer.
- Protection from Environmental Irritants: The barrier formed by occlusives can protect the skin from various environmental factors, such as wind, cold temperatures, and pollutants, which can strip the skin of its natural oils and lead to dryness and irritation.
- Improved Skin Barrier Function: Regular use of occlusives can help to repair and strengthen the skin's natural barrier function. A healthy skin barrier is crucial for preventing the entry of pathogens and reducing the risk of skin infections and irritations.
- Soothing Dry, Cracked Skin: Occlusives are particularly beneficial for dry, cracked, or chapped skin. They lock in moisture and provide a protective layer to promote healing and reduce discomfort.
- Sealing in Other Moisturizing Ingredients: Occlusives are often used with other moisturizing agents, such as humectants and emollients. By sealing in these ingredients, occlusives enhance their effectiveness, ensuring that the skin remains hydrated for longer periods.
Humectants
Humectants has the unique ability to attract and retain moisture from the environment.
Main benefits of Humectants:
- Hydration: Humectants draw water molecules into the skin's outer layer from deeper levels of the skin and, in humid environments, from the air. This hydration helps to improve skin's moisture levels, making it look and feel plump, hydrated, and supple.
- Enhanced Skin Barrier: By promoting hydration, humectants contribute to a healthier skin barrier function. A well-hydrated skin barrier is more effective at protecting against environmental aggressors and less prone to irritation.
- Reduction of Fine Lines and Wrinkles: The hydration provided by humectants can temporarily minimize the appearance of fine lines and wrinkles by plumping up the skin, leading to a smoother, more youthful complexion.
- Improved Skin Texture: Humectants can help to smooth the skin's surface, leading to a softer feel and a more even appearance. This can be particularly beneficial for individuals with dry or flaky skin.
- Promotion of Skin Cell Turnover: By maintaining optimal hydration levels, humectants can support the natural process of skin exfoliation and cell turnover, leading to healthier, more radiant skin.
- Versatility: Humectants are suitable for a wide range of skin types, including oily and acne-prone skin, as they provide moisture without adding oiliness to the skin. This makes them an essential component in various skincare products tailored to different skin needs.
Fatty acids
Essential fatty acids (EFAs) offer a multifaceted approach to improving skin health in patients with eczema and dry skin conditions.
BIOCHEMICAL BRILLIANCE
Essential fatty acids, including omega-3 and omega-6, are the building blocks of the skin's lipid barrier. This barrier is a protective shield, preventing excessive moisture loss and shielding the skin from external aggressors. EFAs play a pivotal role in maintaining this barrier's integrity by contributing to the synthesis of ceramides and lipids that bind skin cells together.
PHARMACOLOGICAL ADVANTAGES
EFAs are not only instrumental in maintaining the skin's structural integrity but also possess anti-inflammatory properties. They serve as precursors for pro-resolving lipid mediators like resolvins and protectins, which help reduce skin inflammation, itching, and redness—common symptoms of eczema.
PHYSIOLOGICAL HARMONY
EFAs contribute to maintaining the balance of skin hydration. They enhance the skin's ability to retain water, leaving it supple and hydrated. Moreover, EFAs can modulate the skin's immune response, reducing the severity of allergic reactions and flare-ups often seen in dermatological conditions like eczema.
d-Panthenol
D-Panthenol stimulates the proliferation of dermal fibroblasts and can accelerate cell turnover.
WOUND HEALING
- D-Panthenol is used in medical wound-healing formulations to help treat skin injuries, burns, and sunburn.
- It's also beneficial after medical and cosmetic surgeries for its wound-healing properties.
- It treats superficial and deep wounds by increasing cell turnover and fibroblast proliferation.
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REPAIR SKIN BARRIER FUNCTION
- D-Panthenol promotes skin barrier repair by enhancing lipid synthesis and epidermal differentiation. This helps hydrate the outermost layer of the skin and locks in moisture.
- D-Panthenol increases the mobility of proteins and lipids in dehydrated skin, improving its elasticity and hydration.
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ANTI-INFLAMMATORY
- Panthenol’s moisturizing properties also contribute to its anti-inflammatory nature.
- Keeping the skin moisturized can help prevent it from becoming sensitive and easily irritated. As such, panthenol can help improve the roughness, dryness, itching, redness, and scaling associated with conditions such as eczema, contact dermatitis, and psoriasis.
- Studies indicate that D-Panthenol may alleviate facial redness from winter xerosis in people with sensitive skin.
Medilan™
KEY BENEFITS
Medilan imitates many functions of human skin lipids, which is nearly twice as effective as the physiological lipids in human skin.
Medilan™ has clinically proven safety and efficacy. It is designed to treat skin barrier impairment and severely compromised skin conditions such as rosacea, eczema, and psoriasis. Its exceptional purity surpasses monograph compliance and performs excellently in clinical trials.
In clinical trials, Medilan maintains skin hydration for up to 2 days after application and increases the rate of epidermal healing by 35% due to its ability to create a moist wound-healing environment.
Medilan™ is hypoallergenic and delivers outstanding efficacy in dermatological applications. Studies have shown no allergic or irritant skin reactions to Medilan, even in severely compromised skin.
Lanolin's efficacy as a medical material and acceptance in the Pharmaceutical Industry is reflected in all major Pharmacopeia containing monographs on lanolin.
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REPLENISHING ESSENTIAL LIPIDS
Medilan™ supplements the skin with the lipids essential to skin health.
Due to its chemical and physical similarity, it imitates and augments many of the skin's natural lipids.
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REPAIRING THE SKIN’S NATURAL BARRIER
Medilan™ effectively accelerates the repair of the skin’s natural barrier function.
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PROTECTING AGAINST MICROBIAL INFECTION
Medilan is proven to control a variety of microorganisms.
- Staphylococcus aureus is a gram-positive bacteria responsible for the infection that leads to inflammatory symptoms in eczema sufferers. Medilan has been proven to reduce colonies of this bacteria by 99% after 24 hours.
- Candidiasis is an overgrowth of yeast that leads to unpleasant symptoms, such as itching and soreness around the skin's mucous membranes. Medilan has been proven to reduce the levels of Candida albicans to a level that controls candidiasis symptoms.
- Pseudomonas aeruginosa is a gram-negative bacteria that can attack wound sites and lead to infection. Wound infection is common in immunocompromised individuals. Medilan has shown potent antibacterial effects against this organism.
Hyaluronic acid
- Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within the body, including wound repair, cell migration, and cell signalling.
- With age, hyaluronic acid in the skin decreases sharply, resulting in a loss of hydration, volume and plumpness. Lines and wrinkles also appear, leaving skin looking dull and lacklustre.
- Hyaluronic acid comes in various molecular sizes. Larger molecules stay on the surface and give the skin a ‘dewy’ look, while smaller molecules penetrate deeper into the skin to deliver their hydration and plumping benefits.
- The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance.
- The cellular and physiological effects of Hyaluronic acid directly depend on the molecular weight of HA present. Therefore, the selection of HA weight is of critical importance.
- High molecular weight: Doesn't penetrate the epidermis.
Very low molecular weight: Penetrate the skin efficiently but can induce a pro-inflammatory response.
Low molecular weight HA [50 kDa]: Penetrates into the skin well and does not cause inflammation.
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HYDRATION
- Hyaluronic acid can bind water up to 1000 times its volume and contributes to cellular growth, adhesion, and membrane receptor function.
- Hyaluronic acid reinforces the intercellular structures and produces the elastoviscous fluid matrix that firmly envelops collagen and elastin fibres.
- Hyaluronic acid holds moisture and provides firmness and radiance to the skin.
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ANTI-AGING
- Hyaluronic acid increases pro-collagen I synthesis and reduce skin roughness.
- Hyaluronic acid has an important role in skin aging. Cells lose their ability to produce Hyaluronic acid with aging. The skin becomes drier, thinner, and looser, leading to wrinkling, among other significant changes.
- Skin aging is also associated with a decrease of skin moisture. Hyaluronic acid has a unique capacity to link and retain water molecules. Hyaluronic acid is a natural component that is present in the whole body. It is naturally and constantly renewed because of its rapid degradation, but its renewal tends to slow with age and external aggressions. Therefore it is necessary to act very early, sustaining an optimal hyaluronic acid turnover, similar to that of young skin, in order to prevent the signs of aging.
- In relation to its biological effects at the skin level, it is known that hyaluronic acid is actively involved in skin cell signalling (by binding the CD44 and LYVE-1 receptors) and thus influences the extracellular matrix (ECM) stability.
- Hyaluronic acid has an impact on the growth of keratinocytes (skin cells) which protect the epidermis from aging and promotes elasticity.
Anti-Aging
NIACINAMINDE
- Stimulates collagen synthesis and increases skin elasticity.
- Prevents collagen and elastin breakdown through antioxidant activity.
- Protects against DNA damage and supports cellular energy, boosting DNA repair and other vital cellular processes.
- Increases ceramide production, enhancing skin barrier strength and hydration.
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SALICYLIC ACID
- Exfoliates by softening and dissolving keratin, which encourages natural cell turnover.
- Reduces fine lines and wrinkles by shedding dead skin cells, promoting a brighter and more even complexion.
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ZINC PCA
- Protects skin from UV-induced collagen degradation. Zinc PCA helps suppress UVA-induced activation of activator protein, which in turn reduces collagenase production—an enzyme responsible for collagen breakdown. This activity helps prevent photoaging and supports skin structure.
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RETINOL
- Prevents collagen and elastin degradation by activating retinoic acid receptors that accelerate skin renewal.
- Boosts collagen production, helping the skin appear more youthful by encouraging the replacement of old cells with fresh ones.
- Reduces inflammation that can accelerate skin aging.