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DermExcel™

Clarify | Salicylic Acid Peel

↓ Sebum

Anti-Acne

Exfoliating

Unclog Pores

↓ inflammation

Superficial peel with comedolytic and anti-inflammatory action.

Potent Salicylic acid chemical peel that provides strong exfoliation and deep mitotic stimulation which will result in increased cellular turnover. It has a sebumetric effect, decreasing sebum production and secretion.

As a lipophilic agent, Salicylic acid removes intercellular lipids and can penetrate the pores to dissolve and extract tough congestion. Salicylic acid has potent anti-inflammatory, antimicrobial and antifungal actions.

15% Salicylic acid

Salicylic acid, a renowned beta hydroxy acid (BHA), stands as a cornerstone in the realm of dermatology and skincare due to its exceptional keratolytic and comedolytic properties. It has a unique ability to penetrate oil-laden hair follicle pores, making it particularly effective in treating acne-prone and oily skin types.

Salicylic acid works by dissolving the type of skin debris that clogs pores and causes acne, namely sebum and dead skin cells. It's a mild anti-bacterial- and a powerful anti-inflammatory agent, which help to reduce the redness and swelling associated with breakouts.

What sets salicylic acid apart in dermatological treatments is its ability to exfoliate the skin not just on the surface, but within the pores themselves. This is due to its oil-soluble nature, allowing it to penetrate deep into the pores and dissolve the keratin plugs that lead to blackheads and whiteheads.

Furthermore, salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions, both in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects of Salicylic Acid

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, making it effective in treating acne located deep within the pores.

Role in Managing Dermatological Conditions

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effective in both preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it useful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used in the treatment of warts due to its ability to exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps in managing seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with keratosis pilaris.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

30% Salicylic acid

Furthermore, Salicylic acid also has the capacity to adjust the pH of the skin, creating an environment less favorable for the growth of acne-causing bacteria. Salicylic acid's efficacy in treating various skin conditions, particularly acne, has been extensively documented in the scientific literature. Studies have consistently shown its ability to reduce acne lesions, both in terms of count and severity. Additionally, salicylic acid is highly recommended for its effectiveness in treating other skin conditions, such as psoriasis and dandruff, due to its ability to soften and remove scales and flakes from the skin.

Physiological Effects

Physiological Effects of Salicylic Acid

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, making it effective in treating acne located deep within the pores.

Role in Managing Dermatological Conditions

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effective in both preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it useful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used in the treatment of warts due to its ability to exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps in managing seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with Keratosis Pilaris.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

USE DURING PREGNANCY

The topical application of salicylic acid on areas of concern is considered safe during pregnancy.

Most guidelines, including those from the American Academy of Dermatology and various obstetric authorities, suggest that topical salicylic acid can be used during pregnancy.

Nevertheless, it is always recommended for pregnant women to consult with their healthcare provider before using any medication, including topical treatments.

SHIPPING

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RETURNS

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Clarify | Salicylic Acid Peel login to view prices

Acne & Congested Pores: Clear existing lesions and prevent future breakouts by reducing redness and inflammation associated with acne.
Oily Skin: Regulate and control excessive sebum production, reducing shine and helping prevent clogged pores.
Inflammatory Skin Conditions: Reduce inflammation associated with various skin conditions, including acne, rosacea, and premature aging.
Folliculitis: Helps alleviate folliculitis by clearing pores, reducing inflammation, and targeting bacteria that can lead to bumps.
Keratosis Pilaris: Reduce the appearance of rough, bumpy skin associated with this condition.

Active ingredients

15% Salicylic acid

Physiological Effects of Salicylic Acid

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, making it effective in treating acne located deep within the pores.

Role in Managing Dermatological Conditions

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effective in both preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it useful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used in the treatment of warts due to its ability to exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps in managing seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with Keratosis Pilaris.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

30% Salicylic acid

Physiological Effects of Salicylic Acid

Keratolytic Action: Salicylic acid is known for its ability to exfoliate the skin by dissolving the intercellular 'glue' that holds skin cells together, helping to remove dead skin cells and unclog pores.
Comedolytic Effect: It is particularly effective in reducing comedones (blackheads and whiteheads) by unclogging pores and preventing the formation of new comedones.
Anti-inflammatory Properties: Salicylic acid reduces inflammation, which is beneficial in treating acne and other inflammatory skin conditions.
Sebum Regulation: It helps to regulate oil production, making it a valuable ingredient for managing oily and acne-prone skin.
Penetration Enhancement: Due to its lipophilic nature, it can penetrate sebum-filled follicles, making it effective in treating acne located deep within the pores.

Role in Managing Dermatological Conditions

Acne Vulgaris: Salicylic acid is a cornerstone in acne treatment, effective in both preventing and treating existing acne lesions.
Psoriasis: Its keratolytic properties make it useful in softening and removing scales associated with psoriasis.
Warts: Salicylic acid is commonly used in the treatment of warts due to its ability to exfoliate and remove the thickened skin.
Seborrheic Dermatitis: It helps in managing seborrheic dermatitis by reducing scaling and redness.
Keratosis Pilaris: Salicylic acid can aid in smoothing the rough bumps associated with Keratosis Pilaris.

References

Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., & Thiboutot, D. M. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945-973.e33.
Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, cosmetic and investigational dermatology, 3, 135.
Zander, E., & Weisman, S. (1992). Treatment of acne vulgaris with salicylic acid pads. Clinical Therapeutics.
Gupta, A. K., & Nicol, K. (2004). The use of sulfur in dermatology. Journal of Drugs in Dermatology.

Full ingredient list

Salicylic acid: 15% | 30%

1. Cleanse

Cleanse the skin with any DermExcel™ Cleanser.

2. Prep

Use the Pre-Peel Solution to remove excess oil from the skin.

3. Treat

Apply 1-2 ml peel solution with cotton buds or brush.
2nd & 3rd layers can be applied depending on disease and patient tolerability.
Peel will self-neutralize after 10-15min. The solution can either be left on for extended action, allowing patients to go home with it, or it can be neutralized and rinsed off before they leave the clinic.

* As a precaution, it is recommended to neutralize the peel for first-time patients to ensure optimal safety and minimize potential sensitivity.

4. Boost (optional)

For increased melanogenesis inhibition, collagen stimulation and hydration apply 1-2 pumps Collagen Serum - or Retinol Serum after neutralizing and gently spread over the treatment area.

5. Protect

Apply any DermExcel™ or Dermaplan™ Moisturizer followed by Dermdefense SPF50.

POST PEEL INSTRUCTIONS

Sun protection is critical. Avoid sun exposure and wear a broad-spectrum sunscreen with a minimum of SPF 30.
Do not pick or pull the skin. Allow skin to peel at its own pace. Premature peeling of the skin will result in dry, cracked, raw skin that may develop into post-inflammatory hyperpigmentation and scarring.
Avoid using chemical exfoliators, physical exfoliators, microdermabrasion, laser treatments, and waxing for 7 days after the peel procedure.
Do not re-apply make-up on the day of the peel procedure. Make-up can be applied from the following day.
Wash twice a day with a gentle cleanser and liberally apply DermNourish after cleansing and throughout the day as needed to prevent dryness and formation of crust.

* Resume all active ingredients after post-peel irritation subsided.

Clarify Peel

mode of action

Regulate sebum

Salicylic acid works well to balance sebum levels because it is lipid or oil-soluble. So, rather than remaining on the skin's surface, salicylic acid penetrates deep into sebum-filled pores.

Bacterial infiltration

When the follicle becomes clogged, a species of bacteria called Cutibacterium acnes (formerly Propionibacterium acnes) accumulates and multiplies in the follicle.
Salicylic acid inhibits the production of various aspects necessary for bacterial reproduction, such as fibrinogen, fibronectin, and alpha-hemolysis.

Exfoliating

Salicylic acid works by loosening and breaking apart desmosomes (attachments between cells in the outer layers of the skin). This action encourages the exfoliation of dead and damaged skin and unclogging pores.
Disrupts cellular junctions to exfoliate dead skin cells.

Keratosis Pilaris

Salicylic acid’s Keratolytic action softens and removes excess keratin buildup in the hair follicles, which causes the rough, bumpy texture of keratosis pilaris. Regular use reduces the appearance of bumps and improves the overall texture of affected skin by facilitating normal cell turnover.
Being lipophilic, Salicylic acid penetrates into the sebaceous components of hair follicles. It exfoliates within the follicular canal, removing debris and reducing the formation of new keratin plugs. This unclogs the follicles, restoring their normal function and preventing the accumulation of keratin over time.
Salicylic acid promotes desquamation by loosening the bonds between dead skin cells. This action accelerates the shedding of rough, dry skin at the surface, improving the overall skin texture and tone in areas affected by keratosis pilaris.

Folliculitis

Folliculitis occurs when hair follicles become inflamed due to blockage, bacterial infection, or irritation. The Clarify Peel effectively addresses this condition by targeting the key factors contributing to follicular inflammation and obstruction. Below is an in-depth explanation of its mode of action:

Salicylic acid breaks down keratin, the protein that can block follicles and trap debris within the follicular opening. By dissolving keratin plugs and clearing the follicular pathway, the peel prevents blockages that contribute to inflammation and infection.
Salicylic acid penetrates the follicular canal and loosens the bonds between dead skin cells, allowing them to shed naturally. This exfoliation eliminates the buildup of dead skin and excess oil that contributes to follicle blockage, creating a clean environment for healthy follicle function.
Salicylic acid is lipophilic, enabling it to dissolve and reduce excess sebum in the follicles. By controlling sebum production, the peel reduces the likelihood of clogged follicles, minimizing the conditions that encourage bacterial growth and inflammation.
Salicylic acid has antibacterial properties that help combat the proliferation of bacteria, such as Staphylococcus aureus or Pseudomonas aeruginosa, commonly implicated in folliculitis. Reducing bacterial colonization prevents secondary infections and promotes faster healing of inflamed follicles.

Anti-inflammatory

Salicylic acid has potent anti-inflammatory effects, inhibiting the arachidonic acid cascade.
Salicylic acid reduces inflammation by modulating COX2 gene expression to decrease the formation of pro-inflammatory cytokines.

Anti-aging

Salicylic acid brightens the complexion. It acts as an exfoliant by softening and dissolving keratin, thus allowing dead skin cells to shed naturally.
Studies have indicated that salicylic acid's exfoliating properties reduce the appearance of fine lines and wrinkles. Over time, exfoliation helps to reduce the thickness of the layer of dead skin cells, giving the skin a brighter, more glowing appearance.